Exsil 100 is a group of silica-based HPLC stationary phases featuring a nominal pore size of 100 Å, specifically designed for the separation of small to medium molecular weight compounds. The well-defined 100 Å pore structure offers an optimal balance between surface area and mass transfer, enabling high chromatographic efficiency, narrow peak shapes, and reproducible retention behavior.
The Exsil 100 platform supports a wide range of bonded phase chemistries, including reversed-phase, normal-phase, polar, ionic, and mixed-mode modifications. This broad chemical flexibility allows Exsil 100 materials to be used in reversed-phase HPLC, normal-phase HPLC, HILIC-type separations, and ion-exchange chromatography, covering a large spectrum of analytical requirements.
Controlled silica synthesis and narrow particle size distribution ensure excellent batch-to-batch consistency, stable selectivity, and robust performance. As a result, Exsil 100 phases are well suited for both routine analytical workflows and demanding method development applications, including UHPLC, microflow, and LC–MS-based separations.
Exsil 100 combines versatile selectivity, reliable performance, and high separation efficiency, making it a robust platform for small-molecule HPLC separations across multiple chromatographic modes.
| Particle Sizes | 1.5 – 12 µm |
|---|---|
| Phases/Modifications | C1, C8, C18, CN, Diol, Hexyl, NH2, Phenyl, SAX, SCX, SH, Si |
| Pore Sizes | 100 Å |
| Surface Areas | 200 m²/g |
Silica-based HPLC media with 100 Å pore size
Optimized for small and medium molecular weight analytes
High surface area for efficient analyte interaction
Broad compatibility with reversed-phase, normal-phase, HILIC, and ion-exchange modes
High chromatographic efficiency and reproducible retention behavior
Available in multiple bonded phase chemistries
Suitable for analytical, microflow, and preparative HPLC
Reversed-phase HPLC of pharmaceuticals and synthetic intermediates
Normal-phase separations of polar organic compounds
HILIC and mixed-mode separations of polar and ionic analytes
Ion-exchange chromatography of small ionic molecules
Method development and routine QC in pharmaceutical, chemical, food, and environmental analysis
| Name | Particle Sizes | Carbon Load | Pore Size |
|---|---|---|---|
| Exsil 100 Amino | 1.5 – 10 µm | 100 Å | |
| Exsil 100 C1 (TMS) | 3 – 10 µm | 100 Å | |
| Exsil 100 Diol | 5 µm | 100 Å | |
| Exsil 100 HAAX | 5 µm | 100 Å | |
| Exsil 100 Hexyl | 5 – 12 µm | 100 Å | |
| Exsil 100 Nitrile | 1.5 – 10 µm | 100 Å | |
| Exsil 100 Nitrile HL | 5 µm | 100 Å | |
| Exsil 100 Octyl | 3 – 10 µm | 5 % | 100 Å |
| Exsil 100 Octyl-AB | 3 – 5 µm | 100 Å | |
| Exsil 100 Octyl-B | 3 – 10 µm | 100 Å | |
| Exsil 100 ODS | 3 – 10 µm | 10 % | 100 Å |
| Exsil 100 ODS-1 | 3 – 10 µm | 100 Å | |
| Exsil 100 ODS-AB | 3 – 10 µm | 100 Å | |
| Exsil 100 ODS-B | 3 – 10 µm | 100 Å | |
| Exsil 100 Phenyl-HL | 3 – 10 µm | 100 Å | |
| Exsil 100 SAX | 5 – 10 µm | 100 Å | |
| Exsil 100 SCX | 3 – 12 µm | 100 Å | |
| Exsil 100 SH | 10 µm | 100 Å | |
| Exsil 100 Si | 1.5 – 10 µm | 0 % | 100 Å |