Polymer particles are spherical beads composed of crosslinked organic polymers, most commonly based on styrene–divinylbenzene (PS/DVB), methacrylate, or related copolymers.
Their structure can be precisely engineered to control particle size, pore volume, and surface functionality, allowing the design of materials optimized for size exclusion, ion exchange, affinity, or reversed phase chromatography.
Unlike silica, polymeric materials exhibit superior chemical and pH stability, enabling use under extreme conditions such as high ionic strength, basic eluents, or aggressive solvents.
Depending on the intended application, these materials can be synthesized as fully porous, macroporous, or nonporous beads, offering flexibility across a broad range of analytical and preparative techniques.
Since their introduction to modern chromatography, polymer particles have become an essential alternative to silica-based materials, particularly in environments where chemical resistance and surface modification flexibility are critical.
They are widely used in ion exchange, gel permeation (GPC), and affinity chromatography, as well as in bioprocessing and catalysis. Their customizable chemistry allows functionalization with a wide variety of ligands — from hydrophobic alkyl groups to ionic or bioaffinity moieties — providing highly specific selectivity and robust column performance.
Excellent chemical and pH stability: Resistant to hydrolysis, strong acids, and bases — ideal for harsh or variable conditions.
Broad solvent compatibility: Suitable for both aqueous and organic systems.
Tailored porosity and surface area: Adjustable pore structure for optimal separation of small molecules or macromolecules.
High mechanical strength: Maintains stable performance under high flow rates and pressure conditions.
Customizable surface functionality: Easily derivatized for ion exchange, affinity, or reversed phase modes.
Low non-specific adsorption: Ensures reproducible peak shapes and high recovery, especially for biomolecules.
Long lifetime and reusability: Durable materials with excellent batch-to-batch reproducibility.
Polymer particles are employed across a wide spectrum of chromatographic and biotechnological fields, including:
Gel Permeation Chromatography (GPC) for molecular weight determination of synthetic polymers.
Ion Exchange Chromatography (IEX) for protein, peptide, and nucleic acid purification.
Affinity and bioseparation systems utilizing immobilized enzymes, ligands, or antibodies.
Reversed Phase Chromatography for hydrophobic compound separations in aqueous or mixed solvents.
Their combination of stability, flexibility, and functional diversity makes polymer particles a key component in modern separation science and materials engineering.
| Name | Particle Sizes | Carbon Load | Pore Size |
|---|---|---|---|
| ReproGel Ca | 9 µm | ||
| ReproGel H | 9 µm | ||
| ReproGel K | 9 µm | ||
| ReproGel Na | 9 µm | ||
| ReproGel Pb | 9 µm | ||
| Repromer Ca | 9 µm | ||
| Repromer H | 9 µm | ||
| Repromer K | 9 µm | ||
| Repromer Na | 9 µm | ||
| Repromer Pb | 9 µm | ||
| ReproGel 50 GPC | 5 – 10 µm | ||
| ReproGel 100 GPC | 5 – 10 µm | ||
| ReproGel 500 GPC | 5 – 10 µm | ||
| ReproGel 1.000 GPC | 5 – 10 µm | ||
| ReproGel 10.000 GPC | 5 – 10 µm | ||
| ReproGel 100.000 GPC | 5 – 10 µm | ||
| ReproGel 1.000.000 GPC | 5 µm | ||
| ReproGel GPC linear (Mixed-bed) | 5 – 10 µm | ||
| ReproGel 100 RP-1 | 5 – 10 µm | ||
| Repromer 100 RPS | 5 – 15 µm | 100 Å | |
| Repromer 300 RPS | 5 – 10 µm | 300 Å | |
| Repromer 1000 RPS | 8 – 10 µm | 1 000 Å | |
| Repromer 2000 RPS | 10 µm | 2 000 Å | |
| Repromer 1000 AX | 10 µm | 1 000 Å | |
| Repromer AX | 5 – 15 µm | 100 Å | |
| Repromer AX-2 | 10 µm | 100 Å | |
| Repromer AXS | 7 µm | 100 Å | |
| Repromer CAT | 7 µm | 100 Å | |
| Repromer SCX | 10 µm | 100 Å | |
| Repromer HLB | N/A | ||
| Repromer SCX 300 | 7 µm | 300 Å | |
| RepromerQ | 10 – 30 µm | N/A | |
| Repromer OH-2500 | 10 µm | ||
| Repromer OH-3000 | 10 µm | ||
| Repromer OH-4000 | 10 µm | ||
| Repromer OH-5000 | 10 µm |