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Chiral
Chiral Chromatography enables the precise separation of enantiomers and stereoisomers with exceptional selectivity and reproducibility — a key technique for pharmaceutical, biochemical, and fine chemical analysis.
Gel Filtration (GFC/SEC)
Gel Filtration Chromatography (GFC), also known as Size Exclusion Chromatography (SEC), gently and reproducibly separates molecules by size in solution for the characterization and purification of water-soluble polymers, proteins, and biopolymers.
Gel Permeation (GPC)
Gel Permeation Chromatography (GPC) separates macromolecules by size in organic solvents, providing a reliable and interaction-free method for determining molecular weight and distribution of synthetic polymers.
HILIC
Hydrophilic Interaction Liquid Chromatography (HILIC) efficiently separates polar and hydrophilic compounds, bridging the gap between reversed phase and normal phase chromatography with full LC-MS compatibility.
Ion Exchange
Ion Exchange Chromatography (IEX) separates charged molecules via electrostatic interactions, providing high selectivity and robustness for proteins, peptides, nucleotides, and other ionic compounds.
Ion Exclusion
Ion Exclusion Chromatography (IEC) selectively separates organic acids, alcohols, and other weakly ionized compounds in aqueous systems by electrostatic exclusion, effectively distinguishing ionic from non-ionic species.
Normal Phase
Normal Phase Chromatography is a powerful liquid chromatography technique for separating polar compounds, offering excellent selectivity for positional, structural, and stereochemical isomers often unresolved by reversed phase methods.
Reversed Phase
Reversed Phase Chromatography is the most widely used HPLC mode, delivering exceptional versatility, reproducibility, and resolution for separating compounds ranging from small molecules to complex biomolecules.
SFC
Supercritical Fluid Chromatography (SFC) combines the efficiency of gas chromatography with liquid chromatography, enabling fast, high-resolution separations of chiral, nonpolar, and thermally sensitive compounds under mild conditions.
Core-Shell
Core–Shell silica particles feature a solid core and porous shell, providing high efficiency, faster separations, and reduced backpressure — the next generation of stationary phase technology for HPLC and UHPLC.
Silica / Fully Porous
Fully porous silica particles form the classical backbone of HPLC, offering high surface area, mechanical stability, and reproducible performance for analytical and preparative separations in all major chromatographic modes.
Silica / Organo Silica
Organosilica hybrid particles unite the mechanical strength of silica with the chemical stability of polymers, offering superior pH tolerance, durability, and long-term stability for modern chromatographic applications.
Silica / Non-Porous
Non-porous silica particles are solid spheres with smooth, high-purity surfaces, ideal for protein, peptide, and affinity separations that require rapid mass transfer, reproducibility, and surface-specific interactions.
Polymer
Polymer particles are versatile, chemically robust materials with tunable porosity and surface chemistry, ideal as stationary phases or functional supports for analytical and preparative chromatographic applications.
C18
C18-functionalized silica phases provide robust, versatile, and high-performance surfaces for reliable reversed-phase chromatographic separations.
C8
C8-functionalized silica phases deliver reliable, efficient, and versatile separations with balanced hydrophobic selectivity in reversed-phase chromatography.
C4
C4-functionalized silica phases offer balanced hydrophobic retention and high recovery, making them a dependable choice for precise separations of peptides and proteins.
C2
C2-functionalized silica phases deliver gentle hydrophobic selectivity and fast, reliable separations for highly polar or early-eluting analytes in reversed-phase chromatography.
C1
C1-functionalized silica phases deliver minimal hydrophobic selectivity and fast, precise separations for highly polar or weakly retained analytes in reversed-phase chromatography.
CN
CN-functionalized silica phases offer versatile polarity and reproducible performance for precise separations in both reversed-phase and normal-phase chromatography.
NH₂
NH₂-functionalized silica phases deliver versatile polar selectivity and robust performance for normal-phase, HILIC, and ion-exchange chromatographic separations.
Phenyl
Phenyl-functionalized silica phases provide reliable aromatic selectivity and balanced hydrophobic interactions for precise and reproducible reversed-phase separations.
SAX
SAX-functionalized silica phases deliver robust anion-exchange selectivity and reliable performance for high-resolution separations of negatively charged analytes.
SCX
SCX-functionalized silica phases offer robust cation-exchange selectivity and reliable, high-resolution separations for positively charged molecules.
Diol
Diol-functionalized silica phases deliver hydrophilic, interaction-minimized surfaces for reliable separations in SEC, normal-phase, and HILIC chromatography.
Si
Bare silica phases deliver strong polar selectivity, high efficiency, and reproducible performance for normal-phase, adsorption, and HILIC separations.
L1
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L58
L59
L60
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L68
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USP Code
L4
L4
Silica gel of controlled surface porosiy bonded to a solid spherical core, 30 to 50 μm in diameter.
Specifications
Particle Sizes
10 µm, 45 µm
Phases/Modifications
Si
Pore Sizes
120 Å
Surface Areas
300 m²/g
Recommended Phases
Reprobond Si
Show all suitable Dr. Maisch columns
Columns suitable for L4
Particle Size
10 µm
45 µm
Pore Size
120 Å
Surface Area
300 m²/g
Modifications
Si
Name
Particle Sizes
Carbon Load
Pore Size
Reprobond Si
10 – 45 µm
0 %
120 Å
L3
L7
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