ReproSil Saphir is a high-end HPLC column series from Dr. Maisch HPLC GmbH, based on ultra-pure, fully porous spherical silica and designed for demanding reversed-phase applications. With advanced C18 bonding and optimized endcapping, ReproSil Saphir columns provide excellent peak shape, low silanol activity, and high separation efficiency — ideal for basic compounds, closely eluting analytes, and method validation.
These columns are particularly suited for use in pharmaceutical quality control, impurity profiling, and regulatory-compliant workflows, where precision and reproducibility are paramount.
ReproSil Saphir columns from Dr. Maisch HPLC GmbH offer premium reversed-phase performance – the ideal choice for laboratories requiring maximum selectivity, reproducibility, and efficiency.
| Particle Sizes | 1.5 – 15 µm |
|---|---|
| Phases/Modifications | C4, C8, C18, Carboxymethyl, NH2, Propyl-SAX, SCX, Si |
| Pore Sizes | 100 Å, 300 Å, 1 000 Å |
| Surface Areas | 30 m²/g, 100 m²/g, 400 m²/g |
Ultra-pure spherical silica with optimized C18 surface chemistry
Excellent peak symmetry, even for basic and polar compounds
High column efficiency and reproducibility
Suitable for gradient and isocratic reversed-phase HPLC
Manufactured under strict quality standards by Dr. Maisch HPLC GmbH
Pharmaceutical impurity profiling and stability testing
Method development and validation in regulated environments
Analysis of basic drugs and polar analytes
Reversed-phase separations requiring sharp peak resolution
| Name | Particle Sizes | Carbon Load | Pore Size |
|---|---|---|---|
| ReproSil Saphir 100 C4 | 5 – 10 µm | 8 % | 100 Å |
| ReproSil Saphir 100 C8 | 5 – 10 µm | 12 % | 100 Å |
| ReproSil Saphir 100 C18 | 1.5 – 10 µm | 20 % | 100 Å |
| ReproSil Saphir 100 NH2 | 5 µm | 4 % | 100 Å |
| ReproSil Saphir 100 SAX | 5 µm | 6 % | 100 Å |
| ReproSil Saphir 100 SCX | 3 – 10 µm | 6 % | 100 Å |
| ReproSil Saphir 300 CM | 5 – 10 µm | 3 % | 300 Å |
| ReproSil Saphir 300 SCX | 5 – 15 µm | 6 % | 300 Å |
| ReproSil Saphir 1000 Si | 10 µm | 0 % | 1 000 Å |
| ReproSil Saphir 1000 C18-2 HE | 7 – 10 µm | 3 % | 1 000 Å |