Exsil Pure 120 ALKAM is an alkaline-modified silica-based HPLC stationary phase built on ultra-high purity Exsil Pure 120 silica with a nominal pore size of 120 Å. The ALKAM surface modification is specifically designed to improve chemical stability and chromatographic robustness under neutral to moderately alkaline mobile phase conditions.
The modified silica surface reduces silica dissolution and minimizes undesired secondary interactions, resulting in improved peak shape and more stable retention behavior, particularly for basic and ionizable analytes. Exsil Pure 120 ALKAM is well suited for reversed-phase HPLC methods where conventional silica phases show limited lifetime or insufficient robustness at elevated pH.
Controlled silica synthesis, very low metal content, and stable surface modification ensure excellent batch-to-batch reproducibility and reliable long-term performance in routine analysis and method development.
Exsil Pure 120 ALKAM combines enhanced alkaline stability with reliable reversed-phase performance, making it a robust solution for small-molecule HPLC separations under demanding pH conditions.
• Alkaline-modified silica-based HPLC phase
• 120 Å pore size optimized for small and medium molecular weight analytes
• Improved chemical stability under neutral to moderately alkaline conditions
• Reduced silica dissolution and secondary interactions
• Improved peak shape for basic and ionizable compounds
• Stable and reproducible retention behavior
• Very low metal content for LC–MS compatibility
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 1.5 µm, 3 µm, 5 µm, 10 µm
• Reversed-phase HPLC of basic and ionizable compounds
• Methods operated at neutral to moderately alkaline pH
• Separation of pharmaceutical APIs and intermediates
• Method development requiring enhanced column lifetime
• Routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 120 Å |
| Surface Area | 230 m²/g |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | No |
| Phase | Material Number |
|---|---|
| Exsil Pure 120 ALKAM, 1.5 µm | 5136589. |
| Exsil Pure 120 ALKAM, 3 µm | 5136590. |
| Exsil Pure 120 ALKAM, 5 µm | 5136591. |
| Exsil Pure 120 ALKAM, 10 µm | 5136592. |