Exsil Pure 120 Amino is an aminopropyl-modified silica-based HPLC stationary phase based on ultra-high purity Exsil Pure 120 silica with a nominal pore size of 120 Å. The bonded amino functionality provides a polar surface with weak anion-exchange properties, enabling versatile retention mechanisms for polar and ionic small molecules.
The 120 Å pore structure offers improved mass transfer and robustness compared to smaller pore materials, making Exsil Pure 120 Amino suitable for demanding analytical workflows. The phase can be operated in normal-phase HPLC, HILIC-type separations, and weak anion-exchange modes, providing flexible selectivity for compounds that are poorly retained on conventional reversed-phase columns.
Controlled silica synthesis, very low metal content, and stable aminopropyl bonding ensure reproducible retention, consistent selectivity, and reliable performance in both routine analysis and method development, including LC–MS-compatible workflows.
Exsil Pure 120 Amino combines high-purity silica, enhanced robustness, and versatile polar selectivity, making it a reliable solution for normal-phase, HILIC, and weak anion-exchange HPLC separations of small molecules.
• Aminopropyl-modified silica-based HPLC phase
• 120 Å pore size optimized for small and medium molecular weight analytes
• Polar surface with weak anion-exchange retention mechanism
• Suitable for normal-phase, HILIC-type, and ion-exchange separations
• Improved mass transfer and robustness compared to 100 Å materials
• Good retention of highly polar and ionic compounds
• Very low metal content for LC–MS compatibility
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 1.5 µm, 3 µm, 5 µm, 10 µm
• Normal-phase HPLC of polar organic compounds
• HILIC-type separations of carbohydrates and highly polar analytes
• Separation of organic acids and small ionic molecules
• Analysis of polar metabolites and pharmaceutical intermediates
• Method development and routine QC in pharmaceutical, chemical, food, and environmental analysis
| Particle Sizes |
|
|---|---|
| Pore Size | 120 Å |
| Surface Area | 230 m²/g |
| Phase/Modification | NH2 |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | No |
| Phase | Material Number |
|---|---|
| Exsil Pure 120 Amino, 1.5 µm | 5136566. |
| Exsil Pure 120 Amino, 3 µm | 5136567. |
| Exsil Pure 120 Amino, 5 µm | 5136777. |
| Exsil Pure 120 Amino, 10 µm | 5136568. |