Exsil Pure 120 C1 (TMS) is a trimethylsilyl-modified silica-based HPLC stationary phase based on ultra-high purity Exsil Pure 120 silica with a nominal pore size of 120 Å. The short-chain C1 (TMS) bonded ligand provides very low hydrophobic surface coverage, resulting in weak reversed-phase retention and enhanced accessibility of the silica surface.
This surface chemistry enables controlled retention of very polar and moderately polar analytes that show insufficient retention on conventional C8 or C18 phases. The 120 Å pore structure improves mass transfer and robustness, delivering stable peak shapes and reproducible selectivity even under demanding analytical conditions.
Controlled silica synthesis, very low metal content, and stable TMS bonding ensure excellent batch-to-batch reproducibility and reliable chromatographic performance in routine analysis and method development.
Exsil Pure 120 C1 (TMS) provides controlled weak reversed-phase retention combined with high-purity silica and robust performance, making it an effective solution for challenging separations of highly polar small molecules.
• Trimethylsilyl (C1, TMS) modified silica-based HPLC phase
• 120 Å pore size optimized for small and medium molecular weight analytes
• Very low hydrophobicity for weak reversed-phase retention
• Fine retention control for highly polar compounds
• Improved mass transfer and robustness compared to 100 Å materials
• Good peak shape and reproducible retention behavior
• Very low metal content for LC–MS compatibility
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 1.5 µm, 3 µm, 5 µm, 10 µm
• Reversed-phase HPLC of highly polar small molecules
• Separation of early-eluting analytes with limited retention on C18 phases
• Analysis of polar pharmaceutical intermediates and metabolites
• Method development requiring fine retention tuning
• Routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 120 Å |
| Surface Area | 230 m²/g |
| Phase/Modification | C1 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Phase | Material Number |
|---|---|
| Exsil Pure 120 C1 (TMS), 1.5 µm | 5136562. |
| Exsil Pure 120 C1 (TMS), 3 µm | 5136563. |
| Exsil Pure 120 C1 (TMS), 5 µm | 5136564. |
| Exsil Pure 120 C1 (TMS), 10 µm | 5136565. |