Exsil Pure 120 C18MS is an octadecyl-modified (C18) silica-based HPLC stationary phase specifically optimized for mass spectrometry–coupled separations. It is based on ultra-high purity Exsil Pure 120 silica with a nominal pore size of 120 Å and features an MS-friendly surface chemistry with extremely low metal content and minimized background activity.
The optimized C18MS surface provides strong and reproducible reversed-phase retention while reducing ion suppression and background signals in LC–MS and LC–MS/MS workflows. Compared to conventional C18 phases, Exsil Pure 120 C18MS offers improved signal stability, excellent peak shape, and reliable performance when using volatile mobile phases and MS-compatible buffers.
Controlled silica synthesis, rigorous purification, and stable C18 bonding ensure consistent selectivity, excellent batch-to-batch reproducibility, and robust long-term performance in demanding analytical environments.
Exsil Pure 120 C18MS combines high-purity silica, robust C18 selectivity, and MS-optimized surface chemistry, making it a reliable choice for sensitive LC–MS-based small-molecule separations.
• MS-optimized octadecyl (C18) modified silica-based HPLC phase
• 120 Å pore size optimized for small and medium molecular weight analytes
• Extremely low metal content for enhanced LC–MS compatibility
• Reduced background and ion suppression effects
• Strong and reproducible reversed-phase retention
• Excellent peak shape with volatile MS-compatible mobile phases
• Improved mass transfer and robustness compared to 100 Å materials
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 1.5 µm, 3 µm, 5 µm, 10 µm
• LC–MS and LC–MS/MS analysis of pharmaceutical APIs
• Bioanalytical and metabolite profiling workflows
• Quantitative MS methods requiring low background signals
• High-sensitivity reversed-phase separations
• Method development and routine QC in pharmaceutical and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 120 Å |
| Surface Area | 230 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Codes | |
| Endcapping | Yes |
| Carbonload | 10 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Exsil Pure 120 C18MS, 1.5 µm | 5136768. |
| Exsil Pure 120 C18MS, 3 µm | 5136772. |
| Exsil Pure 120 C18MS, 5 µm | 5136775. |
| Exsil Pure 120 C18MS, 10 µm | 5136558. |