Exsil Pure 120 Nitrile is a cyanopropyl-modified silica-based HPLC stationary phase based on ultra-high purity Exsil Pure 120 silica with a nominal pore size of 120 Å. The nitrile (CN) bonded ligand provides a moderately polar surface, enabling dual-mode chromatographic behavior that combines characteristics of reversed-phase and normal-phase HPLC.
The 120 Å pore structure improves mass transfer and robustness, delivering stable retention behavior and excellent peak shape across a wide range of mobile phase compositions. Compared to nonpolar reversed-phase materials, Exsil Pure 120 Nitrile offers enhanced selectivity through dipole–dipole interactions, making it particularly useful for fine-tuning separations of polar to moderately nonpolar small molecules.
Controlled silica synthesis, very low metal content, and stable cyanopropyl bonding ensure reproducible retention, consistent selectivity, and reliable long-term performance in routine analysis and method development, including LC–MS-compatible workflows.
Exsil Pure 120 Nitrile combines versatile dual-mode selectivity with high-purity silica and robust chromatographic performance, making it a flexible solution for small-molecule HPLC separations requiring controlled polarity and alternative selectivity.
• Cyanopropyl (nitrile, CN) modified silica-based HPLC phase
• 120 Å pore size optimized for small and medium molecular weight analytes
• Moderately polar surface with dual-mode retention behavior
• Suitable for reversed-phase and normal-phase HPLC
• Enhanced selectivity via dipole–dipole interactions
• Improved mass transfer and robustness compared to 100 Å materials
• Very low metal content for LC–MS compatibility
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 1.5 µm, 3 µm, 5 µm, 10 µm
• Reversed-phase HPLC of polar to moderately nonpolar compounds
• Normal-phase separations requiring controlled polarity
• Selectivity optimization for challenging small-molecule separations
• Analysis of pharmaceutical APIs and intermediates
• Method development and routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 120 Å |
| Surface Area | 230 m²/g |
| Phase/Modification | CN |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Exsil Pure 120 Nitrile, 1.5 µm | 5136569. |
| Exsil Pure 120 Nitrile, 3 µm | 5136570. |
| Exsil Pure 120 Nitrile, 5 µm | 5136571. |
| Exsil Pure 120 Nitrile, 10 µm | 5136572. |