Exsil Pure 120 Phenyl-Hexyl is a mixed-ligand silica-based HPLC stationary phase combining phenyl and hexyl functionalities on ultra-high purity Exsil Pure 120 silica with a nominal pore size of 120 Å. This dual-ligand surface architecture provides a synergistic combination of aromatic π–π interactions and moderate hydrophobic retention.
The phenyl groups enhance selectivity for aromatic and conjugated compounds, while the hexyl chains contribute balanced hydrophobic interactions. This results in differentiated selectivity compared to conventional C18, C8, or phenyl phases, particularly for structurally related analytes and aromatic compounds with varying hydrophobic character.
The 120 Å pore structure improves mass transfer and robustness, delivering stable retention behavior, excellent peak shape, and reproducible chromatographic performance in both routine analysis and method development.
Controlled silica synthesis, very low metal content, and stable dual-ligand bonding ensure excellent batch-to-batch reproducibility and reliable long-term performance, including compatibility with LC–MS workflows.
Exsil Pure 120 Phenyl-Hexyl combines aromatic recognition with balanced hydrophobic retention on a high-purity silica platform, making it a versatile reversed-phase option for challenging small-molecule HPLC separations requiring differentiated selectivity.
• Mixed-ligand phenyl–hexyl modified silica-based HPLC phase
• 120 Å pore size optimized for small and medium molecular weight analytes
• Combined aromatic (π–π) and moderate hydrophobic retention mechanisms
• Enhanced selectivity compared to single-ligand C8, C18, or phenyl phases
• Improved resolution of aromatic compounds with varying hydrophobicity
• Improved mass transfer and robustness compared to 100 Å materials
• Very low metal content for LC–MS compatibility
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle size available in: 5 µm
• Reversed-phase HPLC of aromatic and moderately hydrophobic compounds
• Separation of structurally related pharmaceutical APIs
• Analysis of conjugated and substituted aromatic molecules
• Selectivity optimization in method development
• Routine QC and advanced separations in pharmaceutical, chemical, and analytical laboratories
| Particle Size |
|
|---|---|
| Pore Size | 120 Å |
| Surface Area | 230 m²/g |
| Phase/Modification | Phenyl-Hexyl |
| Particle Type | |
| Separation Mode |
| Phase | Material Number |
|---|---|
| Exsil Pure 120 Phenyl-Hexyl, 5 µm | 6136948. |