Exsil Pure 120 PolaRP is a polar-embedded reversed-phase HPLC stationary phase based on ultra-high purity Exsil Pure 120 silica with a nominal pore size of 120 Å. The PolaRP surface design incorporates polar functional groups within the hydrophobic ligand environment, enabling enhanced retention of polar analytes while maintaining reversed-phase behavior.
This embedded polar functionality reduces undesired silanol interactions and improves peak shape and retention stability, particularly for polar and basic compounds that show insufficient retention or poor symmetry on conventional C18 phases. The 120 Å pore structure enhances mass transfer and robustness, making Exsil Pure 120 PolaRP well suited for demanding analytical workflows and LC–MS-compatible methods.
Controlled silica synthesis, very low metal content, and stable surface modification ensure reproducible retention, consistent selectivity, and reliable long-term performance in routine analysis and method development.
Exsil Pure 120 PolaRP combines reversed-phase robustness with enhanced polar retention, making it an effective solution for challenging small-molecule HPLC separations where conventional alkyl phases provide insufficient selectivity.
• Polar-embedded reversed-phase silica-based HPLC phase
• 120 Å pore size optimized for small and medium molecular weight analytes
• Enhanced retention of polar compounds under reversed-phase conditions
• Reduced silanol activity for improved peak shape
• Stable retention behavior across a wide range of mobile phase compositions
• Improved mass transfer and robustness compared to 100 Å materials
• Very low metal content for LC–MS compatibility
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 1.5 µm, 3 µm, 5 µm, 10 µm
• Reversed-phase HPLC of polar and moderately polar small molecules
• Separation of basic pharmaceutical APIs and metabolites
• Analysis of compounds with limited retention on conventional C18 phases
• Method development requiring enhanced polar selectivity
• Routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 120 Å |
| Surface Area | 230 m²/g |
| Particle Type | |
| Separation Mode |
| Phase | Material Number |
|---|---|
| Exsil Pure 120 PolaRP, 1.5 µm | 5136559. |
| Exsil Pure 120 PolaRP, 3 µm | 5136560. |
| Exsil Pure 120 PolaRP, 5 µm | 5136776. |
| Exsil Pure 120 PolaRP, 10 µm | 5136561. |