Exsil Pure 120 RP18M is a monofunctionally bonded octadecyl-modified (C18) silica-based HPLC stationary phase based on ultra-high purity Exsil Pure 120 silica with a nominal pore size of 120 Å. The monofunctional bonding chemistry results in a uniform and well-defined surface, delivering highly reproducible retention behavior and stable selectivity.
Compared to polyfunctional C18 phases, Exsil Pure 120 RP18M offers reduced secondary interactions and improved surface homogeneity, leading to excellent peak shape and reliable chromatographic performance. The 120 Å pore structure enhances mass transfer and robustness, making the phase suitable for demanding analytical workflows and validated methods.
Controlled silica synthesis, very low metal content, and stable monofunctional C18 bonding ensure excellent batch-to-batch reproducibility and long-term performance, including compatibility with LC–MS applications.
Exsil Pure 120 RP18M combines high-purity silica with uniform monofunctional C18 bonding, making it a reliable reversed-phase solution for small-molecule HPLC separations where reproducibility and robustness are critical.
• Monofunctionally bonded octadecyl (C18, RP18M) silica-based HPLC phase
• 120 Å pore size optimized for small and medium molecular weight analytes
• Uniform surface chemistry for highly reproducible retention behavior
• Reduced secondary interactions and improved peak symmetry
• Strong and stable reversed-phase retention
• Improved mass transfer and robustness compared to 100 Å materials
• Very low metal content for LC–MS compatibility
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 1.5 µm, 3 µm, 5 µm, 7 µm, 10 µm
• Reversed-phase HPLC of pharmaceutical APIs and intermediates
• Routine QC and validated analytical methods
• Separations requiring high reproducibility and robustness
• Method development with strict reproducibility requirements
• General-purpose reversed-phase separations in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 120 Å |
| Surface Area | 230 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 11 % |
| pH Range | 2 - 10 |
| Phase | Material Number |
|---|---|
| Exsil Pure 120 RP18M, 1.5 µm | 5136802. |
| Exsil Pure 120 RP18M, 3 µm | 5136804. |
| Exsil Pure 120 RP18M, 5 µm | 5136805. |
| Exsil Pure 120 RP18M, 7 µm | 6136982. |
| Exsil Pure 120 RP18M, 10 µm | 5136803. |