Exsil Pure 120 SCX is a strong cation-exchange (SCX) silica-based HPLC stationary phase based on ultra-high purity Exsil Pure 120 silica with a nominal pore size of 120 Å. The permanently charged sulfonic acid functional groups provide strong and stable electrostatic interactions, enabling efficient retention and separation of positively charged analytes.
The 120 Å pore structure improves mass transfer and robustness compared to smaller-pore materials, resulting in reproducible retention behavior and stable selectivity across a wide range of mobile phase conditions. Exsil Pure 120 SCX is designed for demanding ion-exchange applications in routine analysis as well as method development, including workflows requiring high reproducibility and robustness.
Controlled silica synthesis, very low metal content, and robust surface modification ensure excellent batch-to-batch reproducibility and reliable long-term chromatographic performance.
Exsil Pure 120 SCX combines strong cation-exchange selectivity with high-purity silica and robust chromatographic performance, making it a reliable solution for ion-exchange HPLC separations of positively charged small molecules.
• Strong cation-exchange (SCX) silica-based HPLC phase
• 120 Å pore size optimized for small and medium molecular weight analytes
• Permanently charged sulfonic acid functional groups
• Strong and stable cation-exchange retention mechanism
• High selectivity for basic and positively charged compounds
• Reproducible retention behavior across a wide pH range
• Improved mass transfer and robustness compared to 100 Å materials
• Very low metal content for LC–MS compatibility
• High batch-to-batch reproducibility
• Suitable for analytical and preparative ion-exchange HPLC
• Particle sizes available in: 1.5 mm, 3 µm, 5 µm, 10 µm
• Ion-exchange HPLC of basic and cationic compounds
• Separation of amines and basic pharmaceutical APIs
• Analysis of ionic pharmaceutical intermediates
• Method development for strong cation-exchange separations
• Routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 120 Å |
| Surface Area | 230 m²/g |
| Phase/Modification | Propyl-SCX |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | No |
| pH Range | 2 - 8 |
| Phase | Material Number |
|---|---|
| Exsil Pure 120 SCX, 1.5 µm | 5136581. |
| Exsil Pure 120 SCX, 3 µm | 5136582. |
| Exsil Pure 120 SCX, 5 µm | 5136583. |
| Exsil Pure 120 SCX, 10 µm | 5136584. |