Exsil Pure 120 ZIK-HILIC is a zwitterionic hydrophilic interaction liquid chromatography (HILIC) stationary phase based on ultra-high purity Exsil Pure 120 silica with a nominal pore size of 120 Å. The surface is functionalized with permanently charged zwitterionic groups, providing a hydrophilic and electrically neutral overall character.
This zwitterionic surface chemistry enables strong and highly reproducible retention of polar and ionic compounds under HILIC conditions while minimizing undesired electrostatic interactions. Exsil Pure 120 ZIK-HILIC delivers stable retention behavior, excellent peak shape, and high robustness, making it particularly suitable for demanding separations of highly polar analytes.
The 120 Å pore structure improves mass transfer and robustness, while the very low metal content ensures compatibility with LC–MS workflows and high-sensitivity analytical methods.
Exsil Pure 120 ZIK-HILIC combines high-purity silica, robust zwitterionic surface chemistry, and excellent reproducibility, making it a powerful solution for challenging HILIC separations of highly polar small molecules.
• Zwitterionic HILIC silica-based HPLC phase
• 120 Å pore size optimized for small and medium molecular weight analytes
• Permanently charged zwitterionic surface with overall neutral character
• Strong and reproducible hydrophilic interaction retention
• Reduced secondary electrostatic interactions
• Excellent peak shape for highly polar and ionic compounds
• Improved mass transfer and robustness compared to 100 Å materials
• Very low metal content for LC–MS compatibility
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HILIC HPLC
• Particle sizes available in: 1.5 µm, 3 µm, 5 µm, 10 µm
• HILIC separations of highly polar small molecules
• Analysis of metabolites, nucleotides, and carbohydrates
• Separation of ionic and zwitterionic compounds
• LC–MS and LC–MS/MS workflows for polar analytes
• Method development and routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 120 Å |
| Surface Area | 230 m²/g |
| Particle Type | |
| Separation Mode | |
| Endcapping | No |
| Phase | Material Number |
|---|---|
| Exsil Pure 120 ZIK-HILIC, 1.5 µm | 6136921. |
| Exsil Pure 120 ZIK-HILIC, 3 µm | 6136922. |
| Exsil Pure 120 ZIK-HILIC, 5 µm | 6136918. |
| Exsil Pure 120 ZIK-HILIC, 10 µm | 6136962. |