Adsorbosphere CN is a cyanopropyl-modified HPLC column offering dual-mode selectivity: it supports both reversed-phase and normal-phase chromatography. The polar cyano functional group enables strong dipole interactions while maintaining moderate hydrophobicity, making it ideal for analytes that are poorly retained or insufficiently separated on C18 or C8 phases.
Built on high-purity, fully porous silica and endcapped, Adsorbosphere CN delivers excellent reproducibility, fast equilibration, and stable retention for polar and aromatic compounds in various matrices.
Adsorbosphere CN is a flexible, polar-selective HPLC column – ideal for analytical tasks requiring dual-mode capability or alternative retention mechanisms.
Cyanopropyl-functionalized silica (USP L10)
Applicable in both reversed-phase and normal-phase modes
Strong dipole interaction for enhanced selectivity of polar analytes
Faster elution for non-polar compounds vs. C18/C8
Available in 3 µm, 5 µm, and 10 µm particle sizes
Suitable for aqueous-organic and non-polar solvent systems
Separation of aromatic and moderately polar compounds
Drug metabolites and degradation products
Pesticide, herbicide, and impurity profiling
Normal-phase separations in lipid or organic analysis
Method development when C18 shows insufficient resolution
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 200 m²/g |
| Phase/Modification | CN |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 6 % |
| Phase | Material Number |
|---|---|
| Adsorbosphere CN, 3 µm | 5200024 |
| Adsorbosphere CN, 5 µm | 5200025 |
| Adsorbosphere CN, 10 µm | 5200026 |