Equisil SCX

Strong Cation Exchange Column for the Separation of Basic and Positively Charged Compounds

Equisil SCX is a strong cation exchange (SCX) HPLC column based on fully porous, high-purity silica, functionalized with sulfonic acid groups. This phase provides permanent negative charges, enabling strong electrostatic retention of positively charged (basic) analytes, including amino acids, basic drugs, and small cationic metabolites. Equisil SCX offers robust and reproducible performance in aqueous buffer systems, making it suitable for routine ion-exchange applications in pharmaceutical, food, and environmental laboratories.

Equisil SCX provides strong cation exchange capabilities with reliable retention – ideal for the precise separation of positively charged compounds in diverse analytical workflows.

Key Features

  • Sulfonic acid functional groups for strong cation exchange

  • High selectivity for basic and positively charged analytes

  • Fully porous silica with stable retention and high reproducibility

  • Suitable for use with aqueous buffers and ion-pairing techniques

  • Available in 5 µm

Typical Applications

  • Amino acids, peptides, and cationic pharmaceutical compounds

  • Polar metabolites and basic excipients

  • Food and beverage additive profiling

  • Ion-exchange chromatography in analytical method development

Specifications

Request Product
Particle Size
  • 5 µm
Pore Size 120 Å
Surface Area 180 m²/g
Phase/Modification SCX
Particle Type
Separation Mode
USP Code
Endcapping No
Carbonload 5 %
pH Range 2 to 8

Material Number

Phase Material Number
Equisil SCX, 5 µm e25.scx.
Equisil SAX Equisil Si

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