Adsorbosphere HS C18 is a high-retention reversed-phase HPLC column based on fully porous silica with a dense octadecyl (C18) surface modification. As part of the HS (High Surface) product line, it is engineered for stronger retention of hydrophobic compounds and enhanced resolution of structurally similar analytes.
With optimized ligand density, endcapping, and surface coverage, Adsorbosphere HS C18 offers improved separation performance for challenging samples — particularly when standard C18 columns are insufficient.
Adsorbosphere HS C18 delivers enhanced reversed-phase selectivity for demanding separations — ideal for applications where ordinary C18 columns reach their limits.
C18-modified silica (USP L1) with high ligand density
Strong retention of non-polar and aromatic compounds
High selectivity for isomers, impurities, and critical pairs
Fully porous silica with consistent surface properties
Available in 3 µm, 5 µm, and 10 µm particle sizes
Suitable for complex reversed-phase applications and method development
Late-eluting hydrophobic pharmaceuticals and drug formulations
Structural isomer and degradant separation
Bioanalytical assays with complex matrices
Environmental pollutants, PAHs, and lipophilic pesticides
Challenging reversed-phase methods requiring extended retention
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 400 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Carbonload | 20 % |
| Phase | Material Number |
|---|---|
| Adsorbosphere HS C18, 3 µm | 5200045 |
| Adsorbosphere HS C18, 5 µm | 5200046 |
| Adsorbosphere HS C18, 7 µm | 5200047 |