Allsphere Cyano is a cyanopropyl-modified HPLC column based on fully porous, high-purity silica. Its polar bonded phase allows the column to operate in both reversed-phase and normal-phase modes. In reversed-phase mode, it provides reduced retention for non-polar analytes and enhanced selectivity for polar compounds. In normal-phase mode, it enables dipole-dipole and hydrogen bonding interactions. This makes Allsphere Cyano a flexible choice for method development and routine analysis of moderately polar substances.
Allsphere Cyano offers reliable performance across multiple chromatographic modes – ideal for laboratories needing flexible retention characteristics.
Cyanopropyl (CN) bonded phase – dual-mode operation (RP and NP)
Moderate polarity and dipole interaction capabilities
Reduced hydrophobic retention compared to C18/C8
Compatible with aqueous-organic and non-polar mobile phases
Available in standard particle sizes (e.g. 3 µm, 5 µm, 10 µm)
Polar pharmaceuticals and drug impurities
Aromatic compounds and electron-withdrawing substituents
Normal-phase separations of neutral organics
Method development requiring alternative selectivity
| Particle Sizes |
|
|---|---|
| Pore Size | 80 Å |
| Surface Area | 220 m²/g |
| Phase/Modification | CN |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | No |
| Carbonload | 7.5 % |
| Phase | Material Number |
|---|---|
| Allsphere Cyano, 3 µm | 5203018 |
| Allsphere Cyano, 5 µm | 5203019 |
| Allsphere Cyano, 10 µm | 5203020 |