ReproSil Chiral-AA is a silica-based HPLC stationary phase modified with a chiral substituent specifically designed for the enantioselective separation of aromatic alcohols and aryl carbinols, particularly those with hydroxyl groups located near the chiral center. The unique chiral selector enables precise enantiodiscrimination through a combination of hydrogen bonding, π–π interactions, and steric recognition, providing excellent resolution and reproducibility for this important compound class.
The chiral recognition mechanism of ReproSil Chiral-AA is tailored to the interaction characteristics of aromatic hydroxyl-containing analytes, making it exceptionally effective for compounds with benzylic or aryl-substituted chiral centers. The phase allows stable, predictable retention behavior and high resolution in normal-phase chromatography, delivering sharp peak shapes and consistent performance across repeated runs. Built on high-purity spherical silica, the stationary phase provides excellent mechanical stability, reproducible retention, and long operational lifetime. It is compatible with common non-aqueous mobile phases such as n-hexane/alcohol mixtures and is suitable for both analytical and preparative applications in pharmaceutical, fine chemical, and research laboratories.
ReproSil Chiral-AA combines a dedicated chiral recognition design with the robustness of high-purity silica – the reliable choice for precise and reproducible enantioselective separations of aromatic alcohols and related compounds in normal-phase chromatography.
Silica-based stationary phase with a covalently bound chiral selector
Specifically designed for aromatic alcohols and aryl carbinols with OH near the chiral center
Strong enantioselectivity through hydrogen bonding, π–π interactions, and steric complementarity
Excellent reproducibility, resolution, and peak symmetry
High mechanical stability and long column lifetime
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of aromatic alcohols, benzylic alcohols, and aryl carbinols
Analysis of chiral intermediates and fine chemicals
Method development for compounds containing aromatic hydroxyl functionalities
Quality control and stereochemical purity determination in pharmaceutical and chemical research
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-AA, 5 µm | r15.aa. |
| ReproSil Chiral-AA, 8 µm | r18.aa. |