Adsorbosil C2

Low-Hydrophobicity Silica Phase for Specialized Reversed-Phase HPLC

Adsorbosil C2 features a short carbon linker bonded phase on high-purity, fully porous silica and is specifically designed for the separation of highly hydrophobic compounds or early-eluting polar analytes. Due to its low carbon load and minimal hydrophobic interaction, this phase is ideal for cases where classical C18 or C8 columns provide excessive retention or poor resolution.

The Adsorbosil C2 phase offers high reproducibility and excellent column stability, making it a reliable tool for both routine and specialized applications in reversed-phase chromatography.

Adsorbosil C2 is the optimal reversed-phase HPLC column for low-retention separations, offering unique selectivity where traditional C8/C18 columns fall short.

Key Features

  • C2-modified silica (USP L7) with low hydrophobicity

  • Ideal for compounds with poor retention on C18 or C8 columns

  • Fully porous silica with consistent surface characteristics

  • Available particle sizes: typically 5 µm, 7 µm and 10 µm

  • Compatible with aqueous-organic mobile phases (MeOH, ACN)

  • High lot-to-lot reproducibility for validated methods

Typical Applications

  • Early-eluting hydrophilic compounds

  • Very hydrophobic analytes that overload longer-chain phases

  • Gradient optimization where minimal hydrophobic retention is needed

  • Applications in food, clinical, and pharmaceutical analysis

Specifications

Request Product
Particle Sizes
  • 5 µm
  • 7 µm
  • 10 µm
Pore Size 60 Å
Surface Area 350 m²/g
Phase/Modification C2
Particle Type
Separation Mode
USP Code
Endcapping No
Carbonload 2 %
pH Range 2 - 8

Material Numbers

Phase Material Number
Adsorbosil C2, 5 µm 5201029.
Adsorbosil C2, 7 µm 5201030.
Adsorbosil C2, 10 µm 5201031.
Adsorbosil C8

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