Adsorbosil CN is a cyanopropyl-modified silica phase offering unique versatility: it can be used in both normal-phase and reversed-phase HPLC applications. The polar cyano functional group provides moderate hydrophobicity and strong dipole interactions, enabling selective retention of polar and aromatic compounds.
Compared to traditional C18 or C8 phases, Adsorbosil CN delivers faster elution for non-polar compounds while enhancing resolution for analytes with polar functional groups. It is also suitable for normal-phase separations using non-polar mobile phases like hexane or heptane.
Adsorbosil CN is the go-to choice for chromatographers needing flexible retention mechanisms and polar selectivity within a single column platform.
Adsorbosil CN is a good alternative to Polygosil® CN.
Cyanopropyl (CN) bonded silica – dual-mode selectivity (USP L10)
Supports both reversed-phase and normal-phase chromatography
Recommended for aromatic and moderately polar compounds
Fully porous, high-purity silica with excellent batch-to-batch consistency
Available in particle sizes of 5 µm and 10 µm
Stable and reproducible retention behavior in both modes
Polar pharmaceuticals, drug metabolites, and impurities
Aromatic compounds with electron-withdrawing groups
Pesticide and herbicide analysis
Normal-phase separations (e.g. lipids, fats, sterols)
| Particle Sizes |
|
|---|---|
| Pore Size | 60 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | CN |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | No |
| Carbonload | 5 % |
| pH Range | 2 - 8 |
| Phase | Material Number |
|---|---|
| Adsorbosil CN, 5 µm | 5201034. |
| Adsorbosil CN, 10 µm | 5201035. |