Adsorbosphere XL C18 is a robust reversed-phase HPLC column based on high-purity, fully porous silica and modified with octadecyl (C18) groups. As part of the XL (Extended Lifetime) product line, this phase features enhanced endcapping and surface treatment designed to reduce silanol activity and improve peak shape — especially for strongly basic analytes.
With excellent chemical and mechanical stability, Adsorbosphere XL C18 is ideal for routine use, validated methods, and long-running sequences in pharmaceutical quality control and GMP-regulated environments.
Adsorbosphere XL C18 is the column of choice for laboratories requiring high durability and consistent performance — especially when analyzing strongly basic compounds in demanding reversed-phase applications.
C18-bonded silica (USP L1) with extended-lifetime bonding chemistry
Optimized endcapping for reduced peak tailing of basic compounds
High resistance to aggressive mobile phases and pH shifts
Reproducible retention over long column lifetimes
Fully porous, high-purity silica support
Available in 3 µm, 5 µm and 10 µm particle sizes
Basic pharmaceuticals (amines, alkaloids, nitrogen-containing drugs)
QC methods with long runtimes or high sample loads
Stability-indicating assays in regulated environments
Routine reversed-phase separations under demanding conditions
Method transfer and validation in GMP/GLP workflows
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 200 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 17 % |
| Phase | Material Number |
|---|---|
| Adsorbosphere XL C18, 3 µm | 5200051 |
| Adsorbosphere XL C18, 5 µm | 5200052 |
| Adsorbosphere XL C18, 10 µm | 5200053 |