Adsorbosphere XL SCX is a strong cation exchange (SCX) HPLC column designed for the separation of positively charged analytes such as basic drugs, amino acids, and small cationic metabolites. Based on high-purity, fully porous silica and modified with strong sulfonic acid groups, this column provides permanent negative charges on the stationary phase, enabling robust and selective ion-exchange retention of protonated compounds.
As part of the XL (Extended Lifetime) product line, it features enhanced chemical stability and surface treatment optimized for reproducibility, durability, and long-term use in buffered aqueous mobile phases.
Adsorbosphere XL SCX delivers robust strong cation exchange performance with extended column lifetime — ideal for demanding analytical workflows involving basic, protonated compounds.
Strong cation exchange (SCX) phase with sulfonic acid functional groups
Stable retention of positively charged (basic) analytes under acidic pH
Long column life and batch-to-batch consistency
Fully porous silica, available in 3 µm, 5 µm and 10 µm particle sizes
Compatible with aqueous buffers, ion-pairing agents, and salt gradients
Ideal for routine, high-throughput, and regulated ion-exchange methods
Separation of basic pharmaceuticals and drug impurities
Amino acids, peptides, and other cationic biomolecules
Cationic food additives, preservatives, and nutrients
Ion-exchange profiling in pharmaceutical formulations
Regulatory testing and method development under acidic conditions
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 200 m²/g |
| Phase/Modification | SCX |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | No |
| Carbonload | 9 % |
| Phase | Material Number |
|---|---|
| Adsorbosphere XL SCX, 3 µm | 5200067 |
| Adsorbosphere XL SCX, 5 µm | 5200068 |
| Adsorbosphere XL SCX, 10 µm | 5200069 |