EcoPrep 120 C18-2 NE is a preparative-scale reversed-phase HPLC column packed with fully porous, high-purity silica, bonded with a C18 stationary phase that is not endcapped. This allows for residual silanol activity, providing enhanced retention and selectivity for polar and ionizable compounds, especially under low-buffer or aqueous conditions.
The non-endcapped surface can be advantageous for preparative methods targeting compounds with partial polarity or when increased interaction with silanol groups is beneficial for resolution. Designed for robustness and reproducibility, EcoPrep 120 C18-2 NE is ideal for scalable workflows in purification and fractionation.
EcoPrep 120 C18-2 NE delivers scalable reversed-phase performance with distinct selectivity – ideal for preparative HPLC involving polar or weakly retained compounds.
Not endcapped C18-2 reversed-phase bonding – USP L1
Enhanced polar selectivity due to active silanol sites
Fully porous 120 Å silica for high loading capacity
Suitable for isocratic or gradient preparative separations
Preparative separation of polar and ionizable analytes
Natural product and intermediate purification
Process development with method-specific selectivity needs
Fractionation workflows where silanol interaction is desired
| Particle Sizes |
|
|---|---|
| Pore Size | 120 Å |
| Surface Area | 320 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | No |
| Carbonload | 25 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| EcoPrep 120 C18-2 NE, 10 µm | 6136845 |
| EcoPrep 120 C18-2 NE, 50 µm | 6136960 |