Exsil 100 Diol is a diol-modified silica-based HPLC stationary phase based on high-purity Exsil 100 silica with a nominal pore size of 100 Å. The bonded diol functionality provides a moderately polar surface with reduced silanol activity, enabling controlled retention and improved peak symmetry compared to bare silica or strongly polar phases.
The balanced polarity of the diol ligand allows Exsil 100 Diol to be operated primarily in normal-phase HPLC and HILIC-type separations. The phase is well suited for analytes that require milder polar interactions, offering stable retention behavior and reduced irreversible adsorption, particularly for sensitive or multifunctional compounds.
Controlled silica synthesis and stable diol bonding ensure excellent batch-to-batch reproducibility, consistent selectivity, and robust chromatographic performance in both routine analysis and method development.
Exsil 100 Diol provides controlled polarity, robust performance, and reliable selectivity, making it a versatile choice for normal-phase and HILIC-based HPLC separations of small molecules.
• Diol-modified silica-based HPLC phase
• 100 Å pore size optimized for small and medium molecular weight analytes
• Moderately polar surface with reduced silanol activity
• Suitable for normal-phase and HILIC-type separations
• Improved peak shape compared to bare silica
• Stable and reproducible retention behavior
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle size available in: 5 µm
• Normal-phase HPLC of polar and moderately polar compounds
• HILIC-type separations of polar analytes
• Separation of carbohydrates, glycosides, and polyols
• Analysis of polar pharmaceutical intermediates
• Method development and routine QC in pharmaceutical, chemical, food, and environmental analysis
| Particle Size |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 200 m²/g |
| Phase/Modification | Diol |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | No |
| Phase | Material Number |
|---|---|
| Exsil 100 Diol, 5 µm | 5136534. |