Exsil 100 Hexyl is a hexyl-modified silica-based HPLC stationary phase built on high-purity Exsil 100 silica with a nominal pore size of 100 Å. The C6-bonded ligand provides moderate hydrophobicity, positioning the phase between short-chain (C1/C4) and long-chain (C8/C18) reversed-phase materials.
This balanced surface chemistry enables controlled reversed-phase retention with reduced hydrophobic interaction strength compared to C18 phases. Exsil 100 Hexyl is particularly suitable for analytes that exhibit excessive retention on C18 columns or insufficient retention on very short-chain phases, offering improved selectivity and optimized elution behavior.
Controlled silica synthesis and stable hexyl bonding ensure reproducible retention, consistent selectivity, and robust chromatographic performance, making Exsil 100 Hexyl suitable for both routine analysis and method development.
Exsil 100 Hexyl provides balanced hydrophobic selectivity and reliable performance, making it a versatile reversed-phase option for small-molecule HPLC separations where controlled retention is required.
• Hexyl (C6)-modified silica-based HPLC phase
• 100 Å pore size optimized for small and medium molecular weight analytes
• Moderate hydrophobicity for balanced reversed-phase retention
• Reduced retention compared to C18 with improved selectivity control
• Good peak shape and reproducible retention behavior
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 5 µm, 12 µm
• Reversed-phase HPLC of moderately polar to moderately hydrophobic compounds
• Separation of pharmaceutical APIs and intermediates
• Analysis of compounds with excessive retention on C18 phases
• Method development requiring fine tuning of hydrophobic selectivity
• Routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 200 m²/g |
| Phase/Modification | Hexyl |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Phase | Material Number |
|---|---|
| Exsil 100 Hexyl, 5 µm | 5136525. |
| Exsil 100 Hexyl, 12 µm | 5136554. |