Exsil Pure 120 Phenyl is a phenyl-modified silica-based HPLC stationary phase based on ultra-high purity Exsil Pure 120 silica with a nominal pore size of 120 Å. The phenyl bonded ligand enables π–π interactions in addition to hydrophobic retention, providing alternative selectivity compared to conventional alkyl reversed-phase materials.
This surface chemistry enhances the separation of aromatic, conjugated, and structurally rigid compounds and allows improved resolution of positional isomers and closely related analytes. The 120 Å pore structure improves mass transfer and robustness, resulting in stable retention behavior, excellent peak shape, and reproducible chromatographic performance in routine analysis and method development.
Controlled silica synthesis, very low metal content, and stable phenyl bonding ensure excellent batch-to-batch reproducibility and reliable long-term performance, including compatibility with LC–MS workflows.
Exsil Pure 120 Phenyl combines aromatic selectivity with high-purity silica and robust chromatographic performance, making it a versatile reversed-phase option for small-molecule HPLC separations requiring alternative selectivity.
• Phenyl-modified silica-based HPLC phase
• 120 Å pore size optimized for small and medium molecular weight analytes
• Enhanced π–π interaction selectivity for aromatic compounds
• Complementary selectivity to C18 and C8 phases
• Improved discrimination of structurally related molecules
• Improved mass transfer and robustness compared to 100 Å materials
• Very low metal content for LC–MS compatibility
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 1.5 µm, 3 µm, 5 µm, 10 µm
• Reversed-phase HPLC of aromatic and conjugated compounds
• Separation of positional isomers and structurally related analytes
• Analysis of pharmaceutical APIs containing aromatic moieties
• Selectivity optimization in method development
• Routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 120 Å |
| Surface Area | 230 m²/g |
| Phase/Modification | Phenyl |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Exsil Pure 120 Phenyl, 1.5 µm | 5136573. |
| Exsil Pure 120 Phenyl, 3 µm | 5136574. |
| Exsil Pure 120 Phenyl, 5 µm | 5136575. |
| Exsil Pure 120 Phenyl, 10 µm | 5136576. |