Exsil Pure 120 RP18 is an octadecyl-modified (C18) silica-based HPLC stationary phase based on ultra-high purity Exsil Pure 120 silica with a nominal pore size of 120 Å. The RP18 surface chemistry provides strong and reliable hydrophobic retention, making the phase suitable for a broad range of reversed-phase HPLC separations of small and medium molecular weight compounds.
The 120 Å pore structure improves mass transfer and column robustness compared to 100 Å materials, resulting in stable retention behavior, excellent peak shape, and reproducible selectivity across a wide range of mobile phase compositions. Exsil Pure 120 RP18 is designed as a dependable reversed-phase standard for routine analysis as well as method development.
Controlled silica synthesis, very low metal content, and stable C18 bonding ensure excellent batch-to-batch reproducibility and long-term chromatographic performance, including compatibility with LC–MS workflows.
Exsil Pure 120 RP18 combines high-purity silica, robust C18 selectivity, and reliable chromatographic performance, making it a trusted reversed-phase solution for small-molecule HPLC separations.
• Octadecyl (C18, RP18) modified silica-based HPLC phase
• 120 Å pore size optimized for small and medium molecular weight analytes
• Strong and reproducible reversed-phase retention
• Excellent peak shape and stable selectivity
• Improved mass transfer and robustness compared to 100 Å materials
• Very low metal content for LC–MS compatibility
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 1.5 µm, 3 µm, 5 µm, 10 µm
• Reversed-phase HPLC of pharmaceutical APIs and intermediates
• Separation of small and medium-sized organic molecules
• Routine QC and validated analytical methods
• Method development and selectivity optimization
• General-purpose reversed-phase separations in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 120 Å |
| Surface Area | 230 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 8 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Exsil Pure 120 RP18, 1.5 µm | 5136767. |
| Exsil Pure 120 RP18, 3 µm | 5136771. |
| Exsil Pure 120 RP18, 5 µm | 5136774. |
| Exsil Pure 120 RP18, 10 µm | 5136557. |