Exsil 80 Nitrile HL is a silica-based HPLC stationary phase with an 80 Å pore size and a high-load nitrile (cyano, CN) bonded surface. The HL (high-load) modification provides an increased ligand density, resulting in enhanced retention capacity and improved robustness for demanding small-molecule separations.
The cyano functionality delivers distinct polar and dipolar interactions and allows operation in both reversed-phase and normal-phase chromatography. Compared to standard CN phases, Exsil 80 Nitrile HL offers higher sample loading, stable retention behavior, and reliable performance in routine analysis and method development.
The controlled pore structure ensures high surface area, supporting sharp peak shapes, high efficiency, and excellent reproducibility.
Exsil 80 Nitrile HL provides enhanced loading capacity, versatile polarity-based selectivity, and reliable performance, making it a robust choice for demanding small-molecule HPLC separations.
Silica-based HPLC stationary phase with 80 Å pore size
High-load nitrile (CN) bonded phase
Increased ligand density for enhanced retention capacity
Suitable for reversed-phase and normal-phase chromatography
Orthogonal selectivity to alkyl-bonded phases
High efficiency and reproducible chromatographic performance
Available particle sizes: 3 µm, 5 µm
Separation of polar and moderately non-polar small molecules
Methods requiring increased sample loading capacity
Reversed-phase HPLC with alternative selectivity to C8 and C18
Normal-phase chromatography of organic intermediates
Pharmaceutical, chemical, food, and environmental analysis
| Particle Sizes |
|
|---|---|
| Pore Size | 80 Å |
| Surface Area | 220 m²/g |
| Phase/Modification | CN |
| Particle Type | |
| Separation Modes | |
| USP Code |
| Phase | Material Number |
|---|---|
| Exsil 80 Nitrile HL, 3 µm | 5136484. |
| Exsil 80 Nitrile HL, 5 µm | 5136497. |