Exsil 80 Nitrile EC is a silica-based HPLC stationary phase with an 80 Å pore size and an endcapped nitrile (cyano, CN) bonded surface. The endcapping (EC) reduces residual silanol activity, resulting in improved peak symmetry, enhanced reproducibility, and more robust performance, particularly for basic and polar analytes.
The cyano functionality provides distinct polar and dipolar interactions and allows operation in both reversed-phase and normal-phase chromatography. Compared to non-endcapped CN phases, Exsil 80 Nitrile EC offers cleaner peak shapes and greater method robustness while maintaining orthogonal selectivity to alkyl-bonded phases.
The controlled pore structure and high surface area support high chromatographic efficiency and reliable retention behavior for small-molecule separations.
Exsil 80 Nitrile EC delivers enhanced peak symmetry, versatile polarity-based selectivity, and reliable performance, making it an effective choice for robust small-molecule HPLC separations.
Silica-based HPLC stationary phase with 80 Å pore size
Endcapped nitrile (CN) bonded phase
Reduced silanol activity for improved peak symmetry
Suitable for reversed-phase and normal-phase chromatography
Orthogonal selectivity to C8 and C18 phases
High efficiency and reproducible chromatographic performance
Available particle size: 5 µm
Separation of polar and moderately non-polar small molecules
Analysis of basic compounds with improved peak shapes
Normal-phase HPLC of organic intermediates
Reversed-phase methods requiring alternative selectivity
Pharmaceutical, chemical, food, and environmental analysis
| Particle Size |
|
|---|---|
| Pore Size | 80 Å |
| Surface Area | 220 m²/g |
| Phase/Modification | CN |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | Yes |
| Phase | Material Number |
|---|---|
| Exsil 80 Nitrile EC, 5 µm | 5136490. |