Exsil Avanti BDS ALKAM is a high-performance alkyl amide bonded silica stationary phase based on the highly purified Avanti BDS silica platform. The phase is carefully bonded with a stable medium-chain alkyl amide functionality, resulting in a unique selectivity profile optimized for challenging basic analytes.
Unlike conventional alkyl-bonded phases on the same silica, Exsil Avanti BDS ALKAM exhibits reduced base retention, delivering improved control of retention behavior for amine-containing compounds. At the same time, peak symmetry for basic analytes is significantly enhanced compared to traditional alkyl phases. Through the optimized bonding procedure, the common issue of acid tailing often observed with standard amide phases is effectively minimized. In addition, Exsil Avanti BDS ALKAM resists phase collapse under low organic conditions, enabling reliable operation even with 100% aqueous mobile phases. Built on high-purity, base-deactivated silica, this phase ensures reproducible retention behavior, strong mechanical stability, and consistent chromatographic performance in both HPLC and UHPLC systems.
Exsil Avanti BDS ALKAM combines advanced base-deactivated silica technology with carefully engineered alkyl amide chemistry — delivering improved peak symmetry, controlled base retention, and enhanced method robustness for challenging reversed-phase separations.
145 Å base-deactivated (BDS) high-purity silica
Stable medium-chain alkyl amide bonding
Reduced base retention compared to conventional alkyl phases
Improved peak shape for basic compounds
Minimized acid tailing through optimized bonding chemistry
Short-term stability up to pH 12
Resistant to phase collapse at low organic content
Compatible with 100% aqueous mobile phases
Separation of basic pharmaceuticals and amine-containing APIs
Analysis of alkaloids and nitrogen-containing organic compounds
Method development requiring controlled base retention
High-pH reversed-phase chromatography (short-term operation)
Routine QC and impurity profiling in pharmaceutical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 145 Å |
| Surface Area | 185 m²/g |
| Phase/Modification | C10 |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | No |
| Carbonload | 9 % |
| pH Range | 2 - 8 |
| Phase | Material Number |
|---|---|
| Exsil Avanti BDS ALKAM, 1.5 µm | 5136661. |
| Exsil Avanti BDS ALKAM, 3 µm | 5136662. |
| Exsil Avanti BDS ALKAM, 5 µm | 5136663. |
| Exsil Avanti BDS ALKAM, 10 µm | 6136985. |