Exsil Avanti C1 (TMS) is a high-efficiency trimethylsilyl bonded silica stationary phase, developed for rapid and controlled reversed-phase HPLC and UHPLC separations. The short methyl functionality provides minimal hydrophobic retention, making it ideal for highly polar, early-eluting, or weakly retained analytes that require fine retention control without excessive interaction strength.
The low hydrophobicity of the C1 surface enables fast elution, reduced analysis times, and improved peak symmetry for compounds that would otherwise elute too late or exhibit broad peaks on longer alkyl phases such as C8 or C18. This makes Exsil Avanti C1 (TMS) particularly suitable for high-throughput analytical workflows and gradient methods requiring sharp peak definition. Built on the advanced Exsil Avanti high-purity spherical silica platform, this phase delivers excellent mechanical stability, uniform particle distribution, and consistent chromatographic performance under high-pressure UHPLC conditions. The optimized surface chemistry minimizes unwanted secondary interactions, resulting in high efficiency and reproducible retention behavior.
Exsil Avanti C1 (TMS) combines ultra-low hydrophobic selectivity with high-efficiency silica technology – the ideal choice for rapid, precise, and reproducible reversed-phase separations of highly polar compounds.
Trimethylsilyl (C1) bonded phase for very mild hydrophobic retention
Ideal for fast reversed-phase HPLC and UHPLC separations
Reduced retention and improved peak symmetry for polar analytes
Excellent efficiency and reproducibility
High-purity spherical silica for mechanical robustness
Compatible with aqueous/organic gradient systems
Fast separation of highly polar or early-eluting compounds
Method development requiring controlled, minimal hydrophobic interaction
High-throughput pharmaceutical and chemical analysis
Gradient RP-HPLC workflows with reduced retention requirements
Analytical screening and routine QC
| Particle Sizes |
|
|---|---|
| Pore Size | 130 Å |
| Surface Area | 195 m²/g |
| Phase/Modification | C1 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 2 % |
| pH Range | 2 - 8 |
| Phase | Material Number |
|---|---|
| Exsil Avanti C1 (TMS), 3 µm | 5136755. |
| Exsil Avanti C1 (TMS), 5 µm | 5136754. |