Exsil Avanti C8 (1) is a high-efficiency octyl (C8) bonded silica stationary phase designed for versatile reversed-phase HPLC and UHPLC applications. This version is not endcapped, preserving residual silanol activity on the silica surface and enabling additional polar interactions that can enhance selectivity for specific analyte classes.
The moderate hydrophobic retention of the C8 bonded phase provides an optimal balance between retention strength and analysis time, making it well suited for small to medium-sized organic molecules. The presence of accessible silanol groups allows secondary interactions such as hydrogen bonding and dipole interactions, which can improve resolution of polar, basic, or structurally similar compounds that require fine selectivity tuning. Built on the advanced Exsil Avanti high-purity spherical silica platform, Exsil Avanti C8 (1) delivers excellent mechanical stability, uniform packing, and reproducible chromatographic performance under high-pressure UHPLC conditions. The phase supports both isocratic and gradient separations using standard aqueous/organic mobile phases.
Exsil Avanti C8 (1) combines balanced C8 hydrophobicity with accessible silanol functionality – delivering enhanced selectivity, reliable performance, and flexible method development in reversed-phase chromatography.
Octyl (C8) bonded phase – non-endcapped version
Moderate hydrophobic retention with enhanced polar selectivity
Residual silanol groups for additional interaction mechanisms
High efficiency and reproducible peak shapes
Robust spherical silica for long column lifetime
Suitable for analytical and preparative reversed-phase HPLC
Reversed-phase separation of small and medium-sized organic compounds
Improved selectivity for polar and basic analytes
Pharmaceutical method development and impurity profiling
Environmental and food analysis
Gradient and isocratic RP-HPLC workflows
| Particle Sizes |
|
|---|---|
| Pore Size | 130 Å |
| Surface Area | 195 m²/g |
| Phase/Modification | C8 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | No |
| Carbonload | 6 % |
| pH Range | 2 - 8 |
| Phase | Material Number |
|---|---|
| Exsil Avanti C8 (1), 3 µm | 5136753. |
| Exsil Avanti C8 (1), 5 µm | 5136638. |
| Exsil Avanti C8 (1), 10 µm | 5136756. |