GromSil 100 ODS-0 AB is a reversed-phase HPLC column from Dr. Maisch HPLC GmbH, packed with fully porous, high-purity silica (100 Å pore size) and bonded with octadecyl (C18) ligands. This phase is only lightly endcapped (type AB), preserving a significant portion of residual silanol groups on the surface. As a result, it offers increased polar and secondary interactions, enabling enhanced retention and selectivity for basic, polar, or ionizable analytes.
Compared to fully endcapped C18 materials, this column provides a more differentiated retention profile — particularly valuable in selectivity screening and method development.
This partially endcapped C18 phase from Dr. Maisch HPLC GmbH offers distinctive polar selectivity — ideal for challenging reversed-phase separations where conventional C18 columns may not deliver sufficient retention or resolution.
Octadecyl (C18) bonded reversed-phase phase with minimal endcapping – USP L1
Fully porous silica with 100 Å pore size
Increased polar and ion-exchange interactions via active silanol groups
Suitable for analytes poorly retained on standard C18 phases
Available in 3 µm, 5 µm, and 10 µm particle sizes
Basic and polar drug substances, ionizable compounds, and isomers
Selectivity scouting and orthogonal method development
LC-MS and UV workflows requiring enhanced secondary interaction
Pharmaceutical profiling and impurity analysis
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| pH Range | 2 - 8 |
| Phase | Material Number |
|---|---|
| GromSil 100 ODS-0 AB, 3 µm | GSOD00310. |
| GromSil 100 ODS-0 AB, 5 µm | GSOD00510. |