GromSil 100 Octyl-4 FE is a reversed-phase HPLC column from Dr. Maisch HPLC GmbH, based on high-purity, fully porous silica with a 100 Å pore size and bonded with octyl (C8) ligands. The phase features full endcapping (FE) to suppress residual silanol activity, enhancing peak symmetry and minimizing tailing — especially for basic or ionizable analytes.
With moderate hydrophobic retention, this column offers shorter run times compared to C18 phases while maintaining strong selectivity and efficiency for small to mid-sized molecules.
This fully endcapped C8 phase from Dr. Maisch HPLC GmbH ensures reliable, reproducible performance — ideal for reversed-phase separations requiring robust peak shape and moderate retention.
Octyl (C8) bonded reversed-phase phase with full endcapping – USP L7
Fully porous silica with 100 Å pore size
Excellent peak shape for basic and polar compounds
Reduced analysis time due to lower hydrophobic retention
Available in 3 µm, 5 µm, and 10 µm particle sizes
Basic drug substances, pharmaceutical impurities, and metabolites
Reversed-phase LC-MS and UV detection workflows
Method development with a focus on peak symmetry and retention control
Routine QC analysis of medium-hydrophobic analytes
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Phase/Modification | C8 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| pH Range | 2 - 8 |
| Phase | Material Number |
|---|---|
| GromSil 100 Octyl-4 FE, 3 µm | GSOC40310. |
| GromSil 100 Octyl-4 FE, 5 µm | GSOC40510. |