GromSil 200 ODS-4 HE is a high-performance reversed-phase HPLC column from Dr. Maisch HPLC GmbH, based on fully porous, high-purity silica with a 200 Å pore size and bonded with octadecyl (C18) ligands. The HE (High-End) surface modification includes advanced endcapping and ultra-clean deactivation, providing excellent peak shape, minimal tailing, and high reproducibility — even for basic, hydrophobic, or high-molecular-weight analytes.
Its wide-pore architecture is ideal for compounds that exceed the accessibility limits of standard 100 Å materials, such as peptides, hydrophobic drug substances, and protein fragments.
With high-end surface chemistry and wide-pore accessibility, GromSil 200 ODS-4 HE from Dr. Maisch HPLC GmbH is the ideal choice for reversed-phase separations of large or structurally complex analytes with demanding retention and peak shape requirements.
Octadecyl (C18) bonded reversed-phase phase with advanced HE surface – USP L1
Fully porous silica with 200 Å pore size for enhanced mass transfer
Excellent peak symmetry and reproducibility for large and basic analytes
Ultra-low silanol activity for minimal secondary interactions
Available in 3 µm, 5 µm, and 10 µm particle sizes
Large peptides, lipophilic pharmaceuticals, and protein fragments
LC-MS and UV detection in pharmaceutical and bioanalytical methods
Stability testing and impurity profiling under regulated conditions
Method development for challenging high-MW or tailing-prone compounds
| Particle Sizes |
|
|---|---|
| Pore Size | 200 Å |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | Yes |
| pH Range | 2 - 8 |
| Phase | Material Number |
|---|---|
| GromSil 200 ODS-4 HE, 3 µm | GSOD40320. |
| GromSil 200 ODS-4 HE, 5 µm | GSOD40520. |
| GromSil 200 ODS-4 HE, 10 µm | GSOD41020. |