GromSil 300 TMS-1 ST is a reversed-phase HPLC column from Dr. Maisch HPLC GmbH, packed with high-purity, fully porous silica featuring a 300 Å pore size and bonded with trimethylsilyl (TMS, C1) groups. This short-chain alkyl phase offers very weak hydrophobic retention, enabling rapid elution of strongly retained, bulky, or highly lipophilic analytes such as peptides, lipid-based compounds, and protein fragments.
The wide-pore design supports efficient mass transfer and analyte accessibility, while standard endcapping (ST) reduces silanol interactions to improve peak shape and reproducibility.
Combining mild retention with wide-pore accessibility, GromSil 300 TMS-1 ST from Dr. Maisch HPLC GmbH is ideal for high-throughput reversed-phase separations of large, hydrophobic analytes requiring fast and efficient elution.
Trimethylsilyl (C1) bonded reversed-phase phase – USP L13 classification
Fully porous silica with 300 Å pore size for large and lipophilic molecules
Minimal hydrophobic retention for fast elution and short run times
Standard endcapping for improved peak symmetry and reproducibility
Available in 5 µm and 10 µm particle sizes
Rapid analysis of peptides, lipophilic drugs, and protein fragments
Reversed-phase separations of strongly retained analytes
Method development requiring minimal retention and sharp peaks
Bioanalytical and pharmaceutical workflows using LC-MS or UV detection
| Particle Sizes |
|
|---|---|
| Pore Size | 300 Å |
| Phase/Modification | TMS (C1) |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| pH Range | 2 - 8 |
| Phase | Material Number |
|---|---|
| GromSil 300 TMS-1 ST, 3 µm | GSTM10330. |
| GromSil 300 TMS-1 ST, 5 µm | GSTM10530. |