GromSil 300 SEC

Wide-Pore Silica Column for Size Exclusion Chromatography of Large Biomolecules

GromSil 300 SEC is a size exclusion chromatography (SEC) column from Dr. Maisch HPLC GmbH, based on high-purity, fully porous silica with a 300 Å pore size. This wide-pore design allows efficient separation of high-molecular-weight compounds based purely on molecular size, making it ideal for the characterization of proteins, monoclonal antibodies, glycoproteins, and large synthetic polymers.

With minimal secondary interactions and high mechanical stability, this phase ensures reproducible retention times and accurate molecular weight profiling in both aqueous and organic solvent systems.

Thanks to its wide-pore structure and minimized surface interactions, GromSil 300 SEC from Dr. Maisch HPLC GmbH is the reliable choice for accurate and robust size exclusion separations of large biomolecules.

Key Features:

  • Silica-based SEC phase with 300 Å pore size for large analytes

  • Fully porous, high-purity silica for precise size-based separations

  • Minimal adsorption and strong reproducibility

  • Compatible with aqueous and organic eluents

  • Available in 5 µm and 10 µm particle sizes

Typical Applications:

  • Molecular weight determination of proteins, mAbs, and glycoproteins

  • Size-based separation of natural and synthetic polymers

  • Aggregate and fragment analysis in biopharmaceuticals

  • SEC method development in bioanalytical and quality control laboratories

Specifications

Request Product
Particle Size
  • 5 µm
Pore Size 300 Å
Particle Type
Separation Modes
USP Code
pH Range 2 - 8

Material Number

Phase Material Number
GromSil 300 SEC, 5 µm GSSE10530.
GromSil 300 ODS-5 ST GromSil 300 TMS-1 ST

Any questions?
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info@dr-maisch.com +49 7073 5035 7

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