ReproSil Mixed-Mode Cyano-C18 from Dr. Maisch HPLC GmbH is a high-purity silica-based HPLC column featuring a mixed-mode stationary phase that combines cyano functionality with octadecyl bonding. This hybrid chemistry delivers both polar interactions and strong hydrophobic retention, enabling orthogonal selectivity for complex mixtures containing analytes of varying polarity. The cyano groups provide enhanced retention and peak shape for polar compounds, while the C18 chains ensure strong retention of hydrophobic analytes, making this column an excellent choice for method development and multi-class compound analysis.
ReproSil Mixed-Mode Cyano-C18 columns from Dr. Maisch HPLC GmbH deliver balanced polar and hydrophobic selectivity – the versatile choice for challenging and diverse HPLC separations.
Fully porous, ultra-pure silica with dual cyano and C18 bonding
Mixed-mode retention: polar interactions + hydrophobic reversed-phase
Broad selectivity range for analytes with diverse polarity
High efficiency and reproducibility for small-molecule analysis
Manufactured and QC-tested by Dr. Maisch HPLC GmbH
Available in 5 µm
Separation of polar and non-polar compounds in one run
Pharmaceutical analysis of APIs and excipients
Complex natural product and metabolite profiling
Method development requiring orthogonal selectivity
| Particle Size |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | C18-CN |
| Particle Type | |
| Separation Modes | |
| USP Codes | |
| Endcapping | Yes |
| Carbonload | 12 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Mixed-Mode Cyano-C18, 5 µm | r15.c9. |