ReproSil Mixed-Mode C18-Acid from Dr. Maisch HPLC GmbH is a high-purity silica-based HPLC column featuring a mixed-mode stationary phase that combines octadecyl bonding with acidic functional groups. This unique chemistry enables simultaneous reversed-phase hydrophobic retention and weak cation-exchange interactions, providing orthogonal selectivity for complex mixtures containing both neutral and basic compounds. The combination of strong hydrophobicity and controlled ionic interactions makes this column ideal for method development and for separations requiring enhanced selectivity compared to conventional reversed-phase columns.
ReproSil Mixed-Mode C18-Acid columns from Dr. Maisch HPLC GmbH deliver dual-mode selectivity and high efficiency – the perfect choice for challenging reversed-phase HPLC applications.
Fully porous, ultra-pure silica with dual C18 and acidic functionality
Mixed-mode retention: hydrophobic reversed-phase + weak cation exchange
Enhanced selectivity for basic and neutral compounds
High efficiency and reproducibility for complex mixture separations
Manufactured and QC-tested by Dr. Maisch HPLC GmbH
Available in 5 µm and 10 µm particle sizes
Separation of basic pharmaceuticals with improved peak shape
Analysis of mixtures with both ionic and non-ionic analytes
Method development requiring orthogonal selectivity
Food, environmental, and natural product testing
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | C18-COOH |
| Particle Type | |
| Separation Modes | |
| USP Codes | |
| Endcapping | No |
| Carbonload | 20 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Mixed-Mode C18-Acid, 5 µm | r15.9ac. |
| ReproSil Mixed-Mode C18-Acid, 10 µm | r10.9ac. |