ReproSil Chiral-AM is a silica-based HPLC stationary phase coated with tris-(3,5-dimethylphenyl)carbamate amylose, specifically developed for enantioselective separations in normal-phase chromatography. The amylose derivative provides multiple interaction mechanisms – including hydrogen bonding, dipole – dipole, and π–π interactions – which enable excellent chiral recognition and high resolution for a broad range of racemic compounds.
The high-purity spherical silica ensures mechanical stability and reproducibility, while the optimized coating process guarantees strong phase adherence and consistent enantioselectivity. ReproSil Chiral-AM is suitable for analytical and preparative separations in pharmaceutical, chemical, and biochemical research, particularly in method development and quality control of chiral active ingredients and intermediates.
ReproSil Chiral-AM combines amylose-based chiral recognition with robust silica stability – the reliable choice for precise and reproducible enantioselective separations in normal-phase chromatography.
Attractive alternative to CHIRALPAK® AD-H (Daicel®) and Lux Amylose-1 (Phenomenex™).
For the use of our ReproSil Chiral-AM columns, please refer to our Column Care Guide.
Silica-based stationary phase coated with tris-(3,5-dimethylphenyl)carbamate amylose
Designed for chiral separations under normal-phase conditions
Excellent enantioselectivity through multiple interaction mechanisms
High reproducibility and mechanical stability
Suitable for analytical and preparative chromatography
Enantioselective separation of chiral pharmaceuticals and intermediates
Quality control and purity testing of optically active compounds
Method development for chiral HPLC in research and production
Analysis of chiral agrochemicals and fine chemicals
| Particle Sizes |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 30 m²/g |
| Phase/Modification | Tris-(3,5-dimethylphenyl)carbamat-Amylose |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-AM, 3 µm | r63.am. |
| ReproSil Chiral-AM, 5 µm | r65.am. |
| ReproSil Chiral-AM, 10 µm | r60.am. |
| ReproSil Chiral-AM, 20 µm | r620.am. |