ReproSil Chiral-MIZ is a silica-based HPLC stationary phase with immobilized tris-(3-chloro-4-methylphenyl)carbamate cellulose, developed for enantioselective separations under normal-phase conditions. The cellulose derivative, substituted with 3-chloro-4-methylphenyl carbamate groups, provides a well-balanced combination of electronic and steric effects, resulting in high chiral recognition capability and excellent resolution across a broad range of racemic compounds.
Chiral discrimination on ReproSil Chiral-MIZ occurs through multiple intermolecular interactions — including hydrogen bonding, π–π stacking, dipole–dipole interactions, and steric complementarity — between analyte molecules and the immobilized chiral selector. The chlorine and methyl substituents on the aromatic rings fine-tune the polarity and π-acceptor properties of the selector, giving the phase a distinct and versatile selectivity profile for compounds with varying functional groups.
The chiral selector is covalently immobilized onto high-purity spherical silica, ensuring exceptional chemical and mechanical stability. This immobilization allows the use of a wide range of mobile phases, including polar and non-standard solvent systems, without loss of enantioselectivity or phase integrity. As a result, ReproSil Chiral-MIZ offers outstanding flexibility for both method development and routine enantioseparations. With its robust design and reproducible performance, ReproSil Chiral-MIZ is ideally suited for pharmaceutical, biochemical, and chemical applications, providing precise, high-resolution separations of chiral compounds under demanding analytical or preparative conditions.
ReproSil Chiral-MIZ combines the proven chiral recognition of cellulose tris-(3-chloro-4-methylphenyl)carbamate with the durability of immobilized silica technology – the reliable choice for accurate, robust, and reproducible enantioselective separations in normal-phase chromatography.
For the use of our ReproSil Chiral-MIZ columns, please refer to our Column Care Guide.
Silica-based stationary phase with immobilized tris-(3-chloro-4-methylphenyl)carbamate cellulose
Designed for enantioselective separations under normal-phase conditions
Strong chiral recognition via hydrogen bonding, π–π stacking, and dipole–dipole interactions
Unique selectivity influenced by chlorine and methyl substituents on the aromatic rings
Covalent immobilization for enhanced chemical and solvent stability
High mechanical strength and reproducible performance
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of pharmaceuticals, intermediates, and fine chemicals
Analysis of racemic mixtures containing aromatic or halogenated substituents
Method development and chiral screening in normal-phase and polar-organic modes
Stereochemical purity testing and quality control in pharmaceutical and chemical research
| Particle Sizes |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 30 m²/g |
| Phase/Modification | Tris-(3-chloro-4-methylphenyl)carbamat-Cellulose |
| Particle Type | |
| Separation Modes | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-MIZ, 3 µm | r63.miz. |
| ReproSil Chiral-MIZ, 5 µm | r65.miz. |
| ReproSil Chiral-MIZ, 10 µm | r60.miz. |