ReproSil Chiral-MIX is a silica-based HPLC stationary phase with immobilized tris-(4-chloro-3-methylphenyl)carbamate cellulose, developed for enantioselective separations under normal-phase conditions. The cellulose derivative substituted with 4-chloro-3-methylphenyl carbamate groups provides highly efficient and versatile chiral recognition through a combination of hydrogen bonding, π–π stacking, dipole–dipole interactions, and steric complementarity, enabling precise and reproducible separations of a wide range of racemic analytes.
The specific substitution pattern of chlorine and methyl groups on the aromatic rings modifies both the electronic and steric environment of the carbamate moieties, resulting in a distinct selectivity profile that allows the resolution of structurally diverse chiral compounds. The immobilization of the cellulose derivative onto high-purity spherical silica ensures exceptional chemical and mechanical stability, allowing the use of polar, non-standard, or mixed mobile phases without loss of enantioselectivity. ReproSil Chiral-MIX combines the proven chiral recognition properties of cellulose-based stationary phases with the robustness and flexibility of immobilized silica technology. It is ideally suited for pharmaceutical, chemical, and biochemical laboratories, offering high-performance enantioselective separations for analytical, semi-preparative, and preparative applications.
ReproSil Chiral-MIX combines the refined chiral recognition of cellulose tris-(4-chloro-3-methylphenyl)carbamate with the enhanced robustness of immobilized silica – the reliable choice for accurate, flexible, and reproducible enantioselective separations in normal-phase chromatography.
For the use of our ReproSil Chiral-MIX columns, please refer to our Column Care Guide.
Silica-based stationary phase with immobilized tris-(4-chloro-3-methylphenyl)carbamate cellulose
Designed for enantioselective separations under normal-phase conditions
Strong chiral recognition via hydrogen bonding, π–π stacking, and dipole–dipole interactions
Distinct electronic and steric properties due to chlorine and methyl substituents
Exceptional chemical and mechanical stability for long column lifetime
Extended solvent compatibility for flexible method development
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of pharmaceuticals, fine chemicals, and intermediates
Resolution of racemic compounds containing aromatic or halogenated functional groups
Method development and chiral screening under normal-phase conditions
Stereochemical purity testing and quality control in pharmaceutical and chemical research
| Particle Sizes |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 30 m²/g |
| Phase/Modification | Tris-(4-chloro-3-methylphenyl)carbamat-Cellulose |
| Particle Type | |
| Separation Modes | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-MIX, 5 µm | r65.mix. |
| ReproSil Chiral-MIX, 10 µm | r60.mix. |