ReproSil Chiral-NR is an immobilized brush-type chiral stationary phase designed for enantioselective separations based on π–electron acceptor/donor interactions. The phase combines chiral recognition elements with aromatic functional groups capable of donor–acceptor complex formation, hydrogen bonding, and dipole–dipole interactions, providing highly selective and efficient resolution of racemic compounds with π–electron-rich or π–deficient moieties.
The immobilized design ensures excellent chemical and mechanical stability, allowing the use of a wide range of organic and mixed solvent systems without loss of selectivity. This robust structure enables reproducible performance even under demanding chromatographic conditions. The well-defined chiral environment of ReproSil Chiral-NR promotes multiple interaction mechanisms between analyte and selector, making it particularly suitable for aromatic, conjugated, and heteroaromatic compounds, as well as for complex pharmaceutical intermediates and fine chemicals. Built on high-purity spherical silica, the phase provides high column efficiency, sharp peak shapes, and long operational lifetime. The immobilized brush-type configuration extends solvent compatibility, ensuring consistent enantioselective performance in normal-phase, reversed-phase, or polar-organic chromatography.
ReproSil Chiral-NR combines immobilized brush-type design with π–electron acceptor/donor functionality – the reliable choice for robust, flexible, and high-resolution enantioselective separations of aromatic and π–conjugated compounds.
Immobilized brush-type chiral stationary phase with π–electron acceptor/donor functionality
Strong chiral recognition through π–π interactions, hydrogen bonding, and dipole–dipole forces
High chemical and mechanical stability for long column lifetime
Extended solvent compatibility for normal-phase, reversed-phase, and polar-organic separations
Designed for enantioselective resolution of aromatic, conjugated, and heteroaromatic compounds
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of aromatic and heteroaromatic pharmaceuticals
Resolution of conjugated π–systems and electron-rich or electron-poor analytes
Method development in π–π interaction-based chiral chromatography
Quality control and stereochemical purity analysis in pharmaceutical and chemical research
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Particle Type | |
| Separation Modes | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-NR, 3 µm | r13.nr. |
| ReproSil Chiral-NR, 5 µm | r15.nr. |
| ReproSil Chiral-NR, 8 µm | r18.nr. |
| ReproSil Chiral-NR, 12 µm | r112.nr. |