ReproSil Chiral-NR-R is an immobilized brush-type chiral stationary phase featuring π–electron acceptor and donor functional groups, specifically developed for enantioselective separations with an inverse elution order compared to ReproSil Chiral-NR. This unique design enables complementary selectivity, providing alternative resolution behavior for compounds that exhibit opposite retention characteristics on the original NR phase.
The chiral selector combines aromatic donor–acceptor sites and stereochemically defined recognition centers, allowing chiral discrimination through π–π interactions, hydrogen bonding, dipole–dipole forces, and steric complementarity. This well-balanced interaction profile delivers precise and reproducible separations for a wide variety of racemic compounds, particularly aromatic, conjugated, and heteroaromatic molecules. The immobilized configuration ensures outstanding chemical and mechanical stability, allowing operation under a broad range of chromatographic conditions — including normal-phase, reversed-phase, and polar-organic modes — without loss of enantioselectivity or phase integrity. Supported by high-purity spherical silica, ReproSil Chiral-NR-R offers high efficiency, excellent column durability, and consistent performance in both analytical and preparative applications.
ReproSil Chiral-NR-R combines immobilized brush-type chiral recognition with π–electron donor/acceptor functionality and reversed elution characteristics – the reliable choice for precise, reproducible, and complementary enantioselective separations in advanced chiral chromatography.
Immobilized brush-type chiral stationary phase with π–electron acceptor/donor functionality
Inverse elution order compared to ReproSil Chiral-NR
Strong chiral recognition through π–π interactions, hydrogen bonding, and dipole–dipole forces
Exceptional chemical and mechanical stability under various solvent conditions
Extended solvent compatibility for flexible method development
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of aromatic, conjugated, and heteroaromatic compounds
Complementary selectivity and inverse elution behavior to ReproSil Chiral-NR
Method development and optimization for complex racemic mixtures
Quality control and stereochemical purity testing in pharmaceutical and chemical research
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Particle Type | |
| Separation Modes | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-NR-R, 3 µm | r13.nrr. |
| ReproSil Chiral-NR-R, 5 µm | r15.nrr. |
| ReproSil Chiral-NR-R, 8 µm | r18.nrr. |
| ReproSil Chiral-NR-R, 12 µm | r112.nrr. |