ReproSil Chiral-XM-R is a silica-based HPLC stationary phase coated with tris-(4-chloro-3-methylphenyl)carbamate cellulose, specifically developed for enantioselective separations under reversed-phase conditions. The cellulose derivative with 4-chloro-3-methylphenyl carbamate substituents provides a unique balance of hydrophobic, π–π, and dipole–dipole interactions, allowing high chiral recognition and selectivity for a wide variety of racemic compounds.
Optimized for aqueous and polar-organic mobile phases, ReproSil Chiral-XM-R delivers robust performance, reproducible retention behavior, and consistent enantioselectivity even under gradient conditions. The polar substituents on the aromatic rings enhance phase stability and interaction diversity, making this phase particularly effective for polar, moderately hydrophobic, and water-soluble chiral analytes. Built on high-purity spherical silica, the phase offers excellent mechanical and chemical stability, ensuring a long column lifetime and reliable performance in both analytical and preparative workflows. ReproSil Chiral-XM-R is ideally suited for applications in pharmaceutical, biochemical, and life-science research, where aqueous compatibility and reproducible chiral separations are essential.
ReproSil Chiral-XM-R combines the strong chiral recognition of tris-(4-chloro-3-methylphenyl)carbamate cellulose with reversed-phase compatibility – the reliable choice for accurate, stable, and reproducible enantioselective separations in aqueous chromatographic systems.
For the use of our ReproSil Chiral-XM-R columns, please refer to our Column Care Guide.
Silica-based stationary phase coated with tris-(4-chloro-3-methylphenyl)carbamate cellulose
Designed for enantioselective separations in reversed-phase and polar-organic modes
High chiral recognition through hydrogen bonding, π–π, and dipole–dipole interactions
Stable and reproducible under aqueous and mixed solvent conditions
High mechanical stability and long column lifetime
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of polar and moderately hydrophobic pharmaceuticals
Analysis of chiral biomolecules, intermediates, and metabolites
Method development in reversed-phase or polar-organic chiral HPLC
Quality control and stereochemical purity testing in pharmaceutical and biochemical research
| Particle Sizes |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 30 m²/g |
| Phase/Modification | Tris-(4-chloro-3-methylphenyl)carbamat-Cellulose |
| Particle Type | |
| Separation Modes | |
| Endcapping | No |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-XM-R, 3 µm | r63.xmr. |
| ReproSil Chiral-XM-R, 5 µm | r65.xmr. |
| ReproSil Chiral-XM-R, 10 µm | r60.xmr. |