ReproSil Chiral-XM is a silica-based HPLC stationary phase coated with tris-(4-chloro-3-methylphenyl)carbamate cellulose, specifically designed for enantioselective separations under normal-phase conditions. The chiral selector, a cellulose derivative substituted with 4-chloro-3-methylphenyl carbamate groups, offers a distinctive balance of electronic and steric effects that enable strong and selective chiral recognition for a wide variety of racemic compounds.
Chiral discrimination on ReproSil Chiral-XM arises from multiple interaction mechanisms — including hydrogen bonding, π–π stacking, dipole–dipole interactions, and steric complementarity — resulting in high resolution and sharp peak shapes. The unique substitution pattern of chlorine and methyl groups on the aromatic rings modifies the electronic environment of the carbamate moieties, providing enhanced selectivity and complementary resolution behavior compared to other cellulose-based chiral stationary phases. The coating on high-purity spherical silica ensures mechanical robustness, reproducible retention behavior, and long column lifetime. ReproSil Chiral-XM performs reliably in standard non-aqueous mobile phases (e.g., n-hexane/alcohol mixtures) and is ideally suited for analytical and preparative separations in pharmaceutical, chemical, and biochemical laboratories.
ReproSil Chiral-XM combines cellulose-based chiral recognition with the unique selectivity of tris-(4-chloro-3-methylphenyl)carbamate functionality – the reliable choice for precise, high-resolution, and reproducible enantioselective separations in normal-phase chromatography.
Attractive alternative to CHIRALCEL® OX-H (Daicel®) and Lux Cellulose-4 (Phenomenex™).
For the use of our ReproSil Chiral-XM columns, please refer to our Column Care Guide.
Silica-based stationary phase coated with tris-(4-chloro-3-methylphenyl)carbamate cellulose
Designed for enantioselective separations under normal-phase conditions
Strong chiral recognition via hydrogen bonding, π–π, and dipole–dipole interactions
Distinct electronic and steric properties for complementary chiral selectivity
High mechanical stability, reproducibility, and long operational lifetime
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of chiral pharmaceuticals, intermediates, and fine chemicals
Method development and screening in chiral HPLC
Analysis of racemic natural products and synthetic compounds
Quality control and stereochemical purity testing in pharmaceutical and chemical research
| Particle Sizes |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 30 m²/g |
| Phase/Modification | Tris-(4-chloro-3-methylphenyl)carbamat-Cellulose |
| Particle Type | |
| Separation Modes | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-XM, 3 µm | r63.xm. |
| ReproSil Chiral-XM, 5 µm | r65.xm. |
| ReproSil Chiral-XM, 10 µm | r60.xm. |