ReproSil Chiral-YM-R is a silica-based HPLC stationary phase coated with tris-(5-chloro-2-methylphenyl)carbamate amylose, specifically designed for enantioselective separations under reversed-phase and polar-organic conditions. The chiral selector, an amylose derivative substituted with 5-chloro-2-methylphenyl carbamate groups, provides highly efficient chiral recognition based on hydrogen bonding, π–π interactions, dipole–dipole forces, and steric complementarity.
Compared to its normal-phase counterpart, ReproSil Chiral-YM-R is optimized for aqueous and polar mobile phases, ensuring stable retention and excellent enantioselectivity without loss of resolution. The presence of both chloro and methyl substituents on the aromatic rings enhances the phase’s polarity balance, offering a distinct and complementary selectivity profile ideal for polar, moderately hydrophobic, or water-soluble analytes. Built on high-purity spherical silica, the phase delivers outstanding mechanical stability, reproducible performance, and a long column lifetime. These properties make ReproSil Chiral-YM-R particularly suitable for biopharmaceutical, pharmaceutical, and biochemical laboratories, where reversed-phase compatibility and robust enantioseparation are required.
ReproSil Chiral-YM-R combines the versatile chiral recognition of amylose tris-(5-chloro-2-methylphenyl)carbamate with reversed-phase compatibility – the reliable choice for accurate, stable, and reproducible enantioselective separations in aqueous and polar chromatographic systems.
Attractive alternative to CHIRALPAK® AY-RH (Daicel®).
For the use of our ReproSil Chiral-YM-R columns, please refer to our Column Care Guide.
Silica-based stationary phase coated with tris-(5-chloro-2-methylphenyl)carbamate amylose
Designed for enantioselective separations in reversed-phase and polar-organic modes
High chiral recognition through hydrogen bonding, π–π, and dipole–dipole interactions
Stable and reproducible under aqueous and mixed solvent conditions
High mechanical stability and long operational lifetime
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of polar and hydrophobic pharmaceuticals and intermediates
Analysis of water-soluble and moderately polar chiral compounds
Method development in reversed-phase chiral HPLC
Quality control and stereochemical purity testing in pharmaceutical and biochemical research
| Particle Sizes |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 30 m²/g |
| Phase/Modification | Tris-(5-chloro-2-methylphenyl)carbamat-Amylose |
| Particle Type | |
| Separation Modes | |
| Endcapping | No |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-YM-R, 5 µm | r65.ymr. |
| ReproSil Chiral-YM-R, 10 µm | r60.ymr. |