ReproSil Chiral-ZA is a silica-based HPLC stationary phase coated with tris-(3-chloro-4-methylphenyl)carbamate amylose, specifically developed for enantioselective separations under normal-phase conditions. The amylose derivative substituted with 3-chloro-4-methylphenyl carbamate groups provides a finely tuned balance of electronic and steric effects, resulting in strong and versatile chiral recognition across a wide range of racemic compounds.
Chiral discrimination on ReproSil Chiral-ZA arises from multiple molecular interactions — including hydrogen bonding, π–π stacking, dipole–dipole interactions, and steric complementarity — allowing excellent resolution and sharp peak shapes. The unique substitution pattern of chlorine and methyl groups modulates the polarity and interaction strength of the carbamate groups, creating a distinct and complementary selectivity compared to other amylose-based chiral stationary phases. The phase is built on high-purity spherical silica, ensuring excellent mechanical strength, reproducibility, and long column lifetime. Its stable coating withstands routine analytical use and is fully compatible with standard non-aqueous mobile phases such as n-hexane/alcohol mixtures. ReproSil Chiral-ZA is ideally suited for both analytical and preparative chiral HPLC in pharmaceutical, chemical, and biochemical laboratories.
ReproSil Chiral-ZA combines amylose-based chiral recognition with the tailored selectivity of tris-(3-chloro-4-methylphenyl)carbamate functionality – the reliable choice for precise and reproducible enantioselective separations in normal-phase chromatography.
Attractive alternative to CHIRALPAK® AZ-H (Daicel®).
For the use of our ReproSil Chiral-ZA columns, please refer to our Column Care Guide.
Silica-based stationary phase coated with tris-(3-chloro-4-methylphenyl)carbamate amylose
Designed for enantioselective separations under normal-phase conditions
Strong chiral recognition via hydrogen bonding, π–π, and dipole–dipole interactions
Unique electronic and steric selectivity due to chlorine and methyl substituents
High mechanical stability and reproducible retention behavior
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of chiral pharmaceuticals and intermediates
Method development and screening in chiral normal-phase HPLC
Analysis of racemic natural products, agrochemicals, and fine chemicals
Stereochemical purity control in pharmaceutical and chemical research
| Particle Sizes |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 30 m²/g |
| Phase/Modification | Tris-(3-chloro-4-methylphenyl)carbamat-Amylose |
| Particle Type | |
| Separation Modes | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-ZA, 3 µm | r63.za. |
| ReproSil Chiral-ZA, 5 µm | r65.za. |
| ReproSil Chiral-ZA, 10 µm | r60.za. |