ReproSil Gold 300 C18

Wide-Pore C18 Column for High-Resolution Large Biomolecule Separations

ReproSil Gold 300 C18 from Dr. Maisch HPLC GmbH is a high-purity silica HPLC column with a 300 Å pore size and an octadecyl bonded phase. The extra-wide pore structure is specifically designed for large biomolecules such as proteins, enzymes, antibodies, and glycoproteins, providing excellent accessibility and mass transfer. The C18 chemistry delivers strong hydrophobic retention and high selectivity for hydrophobic biomolecules. This column ensures sharp peak shapes, high resolution, and reproducible performance in bioanalytical and biopharmaceutical workflows.

ReproSil Gold 300 C18 columns from Dr. Maisch HPLC GmbH combine wide-pore accessibility with strong hydrophobic selectivity – the ideal choice for high-resolution large biomolecule HPLC separations.

Key Features:

  • Fully porous, ultra-pure silica with 300 Å pore size

  • C18 bonding – USP L1 classification

  • Optimized for large proteins, enzymes, and glycoproteins

  • Strong hydrophobic retention with wide-pore accessibility

  • Manufactured and QC-tested by Dr. Maisch HPLC GmbH

  • Available in 3 µm, 5 µm, and 10 µm particle sizes

Typical Applications:

  • Protein and enzyme separations in proteomics

  • Biopharmaceutical QC and characterization of therapeutic proteins

  • Reversed-phase chromatography of large hydrophobic biomolecules

  • Preparative chromatography for biomolecule purification

Specifications

Request Product
Particle Sizes
  • 3 µm
  • 5 µm
  • 10 µm
Pore Size 300 Å
Surface Area 100 m²/g
Phase/Modification C18
Particle Type
Separation Mode
USP Code
Endcapping Yes
Carbonload 8 %
pH Range 2 to 9

Material Numbers

Phase Material Number
ReproSil Gold 300 C18, 3 µm r33.9g.
ReproSil Gold 300 C18, 5 µm r35.9g.
ReproSil Gold 300 C18, 10 µm r30.9g.
ReproSil Gold 300 C8

Any questions?
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info@dr-maisch.com +49 7073 5035 7

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